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Monitoring glucose levels is essential for ensuring safe delivery and reducing the risks to both the mother and fetus. Various sensors are readily available for monitoring glucose levels, and researchers are continually working to develop highly sensitive glucose sensors. This research aimed to develop a gold nanourchin (AuNU)\u2010hybrid biosensor for quantifying glucose on a multi\u2010point electrode sensor. Glucose oxidase (GOx) was attached to the AuNU and seeded on the sensing surface using an amine linker. The current\u2010potential (1\u20132\u00a0V at 0.1\u00a0V sweep) was recorded for the GOx\u2013glucose interaction, with a limit of detection of 560\u00a0\u03bcM and a regression coefficient (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>) of 0.9743 [<jats:italic>y<\/jats:italic> = 0.9106<jats:italic>x<\/jats:italic> \u2212 0.9953] on the linear curve. The sensitivity was estimated to be 3.5\u00a0mAcm<jats:sup>\u22122<\/jats:sup>M<jats:sup>\u22121<\/jats:sup>. Furthermore, control experiments with galactose, sucrose, and fructose did not yield an increase in current\u2010potential, confirming specific glucose detection. This experiment helps in monitoring glucose levels to manage conditions associated with GD.<\/jats:p>","DOI":"10.1002\/bab.2626","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T05:33:37Z","timestamp":1718256817000},"page":"1262-1271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gold nanourchin on multiple\u2010point dielectrode for glucose biosensing by current\u2010potential measurement"],"prefix":"10.1002","volume":"71","author":[{"given":"Wei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Obstetrics (Guoxing) Haikou Hospital of The Maternal and Child Health  Haikou Hainan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics (Guoxing) Haikou Hospital of The Maternal and Child Health  Haikou Hainan Province 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