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In this study, a mercaptoundecanoic acid (MUA)\u2010capped gold nanorod (GNR)\u2010coated and chitosan (CH)\u2010immobilized fiber optic probe has shown considerable sensitivity of its detection. The proposed U\u2010shaped fiber optic biosensor based on localized surface plasmon resonance (LSPR) was applied to detect \u03b1\u2010syn oligomer (OA) biomarker. By analyzing OA concentrations, the biosensor achieved a limit of detection of (LOD) 11\u00a0pM within the concentration range of 10\u2013100\u00a0pM and the sensitivity value was found as 502.69 \u0394\u03bb\/RIU. Upon analysis of the CV% (coefficient of variation) and accuracy\/recovery values, it is revealed that the sensor successfully fulfilled the criteria for success, displaying accuracy\/recovery values within the range of 80%\u2013120% and CV% values below 20%. This sensor presents significant advantages, including high sensitivity, specificity, and ability to detect very low concentrations of OA. In conclusion, the suggested U\u2010shaped fiber optic biosensor has the potential to be valuable in the early detection of PD from a clinical perspective.<\/jats:p>","DOI":"10.1002\/bab.2653","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T06:33:06Z","timestamp":1725431586000},"page":"150-163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Chitosan\u2010enhanced sensitivity of mercaptoundecanoic acid (MUA)\u2010 capped gold nanorod based localized surface plasmon resonance (LSPR) biosensor for detection of alpha\u2010synuclein oligomer biomarker in parkinson\u2019s disease"],"prefix":"10.1002","volume":"72","author":[{"given":"Begum Balkan","family":"Apayd\u0131n","sequence":"first","affiliation":[{"name":"Institute of Biomedical Engineering Bo\u011fazi\u00e7i University Istanbul 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