{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T06:22:59Z","timestamp":1772950979454,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:00:00Z","timestamp":1726358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biotech and App Biochem"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is a common immune\u2010related polygenic inflammatory skin disease. Salidroside (SAL) exerts anti\u2010inflammatory and antioxidant effects and is used to treat skin diseases. However, the specific effects of SAL on psoriasis remain unclear. In this study, we aimed to investigate the efficacy of SAL for psoriasis treatment. Mice were treated with imiquimod (IMQ) to establish an in vivo psoriasis model. Histological analysis was conducted via hematoxylin and eosin staining. Cytokine release was determined via enzyme\u2010linked immunosorbent assay. Additionally, mRNA levels were determined via reverse transcription\u2010quantitative polymerase chain reaction. Protein expression was assessed via Western blotting. Gasdermin D (GSDMD) and Ki\u201067 expression levels were determined via immunohistochemistry. Caspase 1 and GSDMD expression levels were determined via immunofluorescence assay. Furthermore, macrophage function and keratinocyte pyroptosis were also analyzed via flow cytometry. Cell proliferation was determined using 5\u2010ethynyl\u20102\u02b9deoxyuridine assay. SAL alleviated IMQ\u2010induced psoriasis. IMQ\u2010mediated GSDMD\u2010driven pyroptosis and keratinocyte hyperproliferation promoted M1 macrophage polarization. However, SAL treatment suppressed GSDMD expression, thereby inhibiting keratinocyte proliferation and pyroptosis and promoting M2 macrophage polarization. GSDMD deficiency further promoted the effects of SAL and suppressed psoriasis progression. Overall, our findings suggest that SAL exerts protective effects against psoriasis. Specifically, it exerts anti\u2010inflammatory effects by regulating M2 macrophage polarization and inhibiting keratinocyte pyroptosis\u2010driven proliferation induced by the immune microenvironment in psoriasis.<\/jats:p>","DOI":"10.1002\/bab.2668","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T06:20:25Z","timestamp":1726467625000},"page":"355-368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Salidroside alleviates imiquimod\u2010induced psoriasis by inhibiting GSDMD\u2010driven keratinocyte pyroptosis"],"prefix":"10.1002","volume":"72","author":[{"given":"Mengjie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology and Surgery Baotou Medical College of Inner Mongolia University of Science and Technology  Baotou 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