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This study included 60 subjects who were clinically diagnosed cases with active psoriasis (categorized further into 33 mild to moderate and 27 severe cases based on the Psoriasis Area Severity Index score) and 60 age\u2010 and gender\u2010matched healthy control subjects. Levels of TNF\u2010\u03b1, IFN\u2010\u03b3, IL\u20102, and IL\u201010 in the unstimulated saliva of subjects were determined via enzyme\u2010linked immunosorbent assay (BT Lab). The salivary levels of TNF\u2010\u03b1, IFN\u2010\u03b3, and IL\u20102 were significantly higher, whereas IL\u201010 concentration was significantly reduced in psoriatic patients in comparison to controls, and the difference increased with the progressing severity of the disease. Assessment of cytokine profiles in psoriasis patients is significant for diagnostic validation and monitoring the disease severity. Saliva offers an alternate, noninvasive, and readily available biological sample for evaluating cytokine levels. Extensive research in this field has been recommended for better scientifically proven conclusions.<\/jats:p>","DOI":"10.1002\/bab.2669","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T07:35:51Z","timestamp":1726212951000},"page":"369-376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dysbiosis of pro\u2010inflammatory and anti\u2010inflammatory salivary cytokines during psoriasis providing a therapeutic window and a valuable diagnostic aid in future"],"prefix":"10.1002","volume":"72","author":[{"given":"Ravi Kant","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Dr. Harvansh Singh Judge Institute of Dental Sciences &amp; Hospital Panjab University  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manu Rashmi","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Health and 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