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The groups included the control, ethanolic extract of propolis, vitamin E, dimethylhydrazine, dimethylhydrazine + ethanolic extract of propolis, and dimethylhydrazine + vitamin E. After 13 weeks of treatment, the blood and tissue samples were taken from all the rats, and alanine transaminase, aspartate transaminase, alkaline phosphatase, uric acid, creatinine, blood urea nitrogen, insulin, amylase, and lipase indices along with the tissue pathological examination of the kidney, liver, and pancreas were evaluated. Ethanolic extract of propolis effectively alleviated the colorectal cancer\u2010induced secondary lesions in the liver by significantly lowering the alanine transaminase significantly. Ethanolic extract of propolis significantly decreased uric acid in rats; and also significantly elevated the pancreatic insulin. In addition, inflammation and cell necrosis indices in all these tissues were significantly reduced when ethanolic extract of propolis was consumed compared to the dimethylhydrazine group. It seemed ethanolic extract of propolis showed high antioxidant, anticancer, and anti\u2010inflammatory potentials, and can be used practically to reduce the side lesions of colorectal cancer.<\/jats:p>","DOI":"10.1002\/bab.2674","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T14:47:43Z","timestamp":1727275663000},"page":"437-448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Propolis ameliorates renal, liver, and pancreatic lesions in Wistar rats"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3764-8113","authenticated-orcid":false,"given":"Alireza","family":"Salehi","sequence":"first","affiliation":[{"name":"Department of Comparative Biomedical Sciences, School of Advanced Medical Sciences and Technologies Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6015-3832","authenticated-orcid":false,"given":"Seyed Mohammad","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Department of Pathology Babol Branch, Islamic Azad University  Babol Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8068-5745","authenticated-orcid":false,"given":"Sohrab","family":"Kazemi","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Biology Research Center, Health Research Institute Babol University of Medical Sciences  Babol Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i2.193"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-8153"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-015-0428-2"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2021.103187"},{"key":"e_1_2_10_6_1","article-title":"Extraluminal colonic carcinoma invading into kidney: a case report and review of the literature","volume":"2011","author":"Nelson J","year":"2011","journal-title":"ISRN Urol"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.2013.1195"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjab629"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10813"},{"key":"e_1_2_10_10_1","unstructured":"GrivennikovSI. 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