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The potency of rutecarpine, a phytochemical, in mitigating cisplatin\u2010induced nephrotoxicity was assessed in the present study. In this experimental setup, healthy male Wistar rats were grouped into four and Group I rats served as the control group, receiving only vehicle control. Group II rats were subjected to cisplatin treatment alone, administered intraperitoneally at a dosage of 7\u00a0mg\/kg body weight on the 19th, 20th, and 21st days. Group III and IV rats were orally administered with rutecarpine at doses of 10 and 20\u00a0mg\/kg body weight, respectively, starting from Day 1 and continuing daily for 21 days. Additionally, they were injected intraperitoneally with cisplatin at the same dosage and schedule as Group II. Relative kidney weight and renal biochemical markers blood urea nitrogen, lactate dehydrogenase, serum urea, and creatinine were measured to assess rutecarpine inhibitory potency against cisplatin toxicity. Markers of oxidative damage and antioxidants levels were quantified in the ruteacarpine\u2010 and cisplatin\u2010treated rats. The study investigated the anti\u2010inflammatory property of rutecarpine in cisplatin\u2010induced nephrotoxicity by analyzing inflammatory cytokines. Renal tissue levels of monocyte chemoattractant protein\u20101, intercellular adhesion molecule\u20101, high\u2010mobility group box 1, and nuclear factor kappa B, key markers of nephrotoxicity, were quantified to assess rutecarpine's potential to mitigate cisplatin\u2010triggered damage. Histopathological examinations were performed to confirm the impact of rutecarpine against cisplatin\u2010induced nephrotoxicity. Treatment with rutecarpine notably reduced renal biochemical markers, prevented renal edema, and attenuated oxidative stress\u2010induced damage in cisplatin\u2010treated rats. Both inflammatory and nephrotoxicity markers showed significant decreases in rats treated with rutecarpine along with cisplatin. Histological analysis affirmed that rutecarpine pretreatment effectively prevented cisplatin\u2010induced nephrotoxicity. The study findings demonstrate that rutecarpine ameliorates cisplatin\u2010triggered nephrotoxicity through its antioxidant and anti\u2010inflammatory properties, suggesting that rutecarpine supplementation alongside cisplatin treatment could potentially reduce nephrotoxicity in cancer patients.<\/jats:p>","DOI":"10.1002\/bab.2692","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:43:32Z","timestamp":1730940212000},"page":"718-729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ameliorative effect of rutecarpine supplementation against cisplatin\u2010induced nephrotoxicity in rats via inhibition of monocyte chemoattractant protein\u20101, intercellular adhesion molecule\u20101, high\u2010mobility group box 1, and nuclear factor kappa B"],"prefix":"10.1002","volume":"72","author":[{"given":"Dong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of 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