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Throughout history, plants and plant\u2010derived food products have been utilized for medicinal purposes, demonstrating their efficacy in the treatment and prevention of various diseases. <jats:italic>Gundelia tournefortii<\/jats:italic> (GT), a plant of interest, is known to possess beneficial properties. Hence, this study aimed to investigate the immunotoxic and neurotoxic effects of two different doses of GT plant extract on the liver, brain, and heart tissues of obese rats. For this purpose, Wistar male rats were divided into four groups: \u201cCG,\u201d \u201cHCDG,\u201d \u201cHCDGUN1,\u201d and \u201cHCDGUN2\u201d At the conclusion of the study, adenosine deaminase (ADA) and myeloperoxidase (MPO) activities, as well as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) biomarkers, were evaluated in the liver, heart, and brain tissues. The study results revealed a statistically significant increase in ADA and MPO activities in the HCDG group compared to the CG group, alongside a significant decrease in the HCDGUN groups compared to the HCDG group. Regarding AChE and BChE activities, a statistically significant decrease was observed in the HCDG group compared to the CG group, whereas an increase was noted in the HCDGUN groups relative to the HCDG group, with the latter approaching values similar to those of the control group. In conclusion, the intake of GT plant extract exhibited positive effects on the immunotoxic and neurotoxic effects induced by HCD in rats with an experimental obesity model, as evidenced by tissue biomarker evaluations.<\/jats:p>","DOI":"10.1002\/bab.2694","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T01:11:12Z","timestamp":1730855472000},"page":"743-754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Organ toxicities associated with diet\u2010induced obesity in rats: Investigation of changes in activities selected enzymes"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9501-7822","authenticated-orcid":false,"given":"Bedia","family":"Bati","sequence":"first","affiliation":[{"name":"Department of Mathematics and Science Education, Faculty of Education Van Yuzuncu Yil University  Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2012.08.007"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184556"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/1519\u20106984.251198"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9050519"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.48138\/cjo.934158"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150735"},{"key":"e_1_2_9_8_1","unstructured":"WOF World Obesity Federation.World obesity atlas 2023;2023[cited 2023 Aug 30].https:\/\/data.worldobesity.org\/publications\/?cat=19"},{"issue":"4","key":"e_1_2_9_9_1","article-title":"Possible roles of dietary phytochemicals in the prevention and treatment of obesity","volume":"78","author":"Turan Demirci B","year":"2021","journal-title":"Turk Bull Hyg Exp Biol"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.18697\/ajfand.56.11000"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccmp.2022.100035"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679\u2010018\u20100300\u20104"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2015.08.001"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4620251"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2005.12.008"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745\u20104514.2010.00449.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2010.07.069"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3923\/pjbs.2013.1238.1247"},{"issue":"28","key":"e_1_2_9_19_1","first-page":"112","article-title":"Effect of Gundelia tournefortii L. on some cardiovascular risk factors in animal model","volume":"7","author":"Asgary S","year":"2008","journal-title":"J Med Plants"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.33899\/ijvs.2012.67458"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.22127\/rjp.2018.69223"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2022.111774"},{"key":"e_1_2_9_23_1","first-page":"323","article-title":"Plasma cholinesterase correlations in acute surgical and critical illness","volume":"66","author":"Chiarla C","year":"2011","journal-title":"Minerva Chir"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102020\u2010042857"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117585"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049\u20103848(03)00178\u20106"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2018.12.005"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2008.06.016"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.21608\/jesp.2021.165947"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2015.10.005"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2012.11.037"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20107580.2008.00902.x"},{"key":"e_1_2_9_33_1","unstructured":"OECD.Guidelines for the testing of chemicals.OECD;2008. 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