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In this study, triazole\u2010based\n                    <jats:italic>p<\/jats:italic>\n                    \u2010\n                    <jats:italic>tert<\/jats:italic>\n                    \u2010butylcalix[4]arene conjugates (\n                    <jats:bold>AT10a<\/jats:bold>\n                    and\n                    <jats:bold>AT10b<\/jats:bold>\n                    ) and their\n                    <jats:italic>p<\/jats:italic>\n                    \u2010\n                    <jats:italic>tert<\/jats:italic>\n                    \u2010butylphenol analogs (\n                    <jats:bold>AT10b<\/jats:bold>\n                    and\n                    <jats:bold>AT11b<\/jats:bold>\n                    ) were synthesized in good yields and characterized using\n                    <jats:sup>13<\/jats:sup>\n                    C NMR and\n                    <jats:sup>1<\/jats:sup>\n                    H NMR experiments. The compounds were evaluated for their antimicrobial (AM) activity against Gram\u2010positive bacteria (\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ,\n                    <jats:italic>Enterococcus faecalis<\/jats:italic>\n                    ,\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    ), Gram\u2010negative bacteria (\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Salmonella typhi<\/jats:italic>\n                    ,\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    ), and fungi (\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    ,\n                    <jats:italic>Candida tropicalis<\/jats:italic>\n                    ), and minimal\/minimum inhibitory concentration (MIC) values varied from 19 to 2500\u00a0\u00b5g\/mL. The AM activities of the compounds were good against most of the strains, with\n                    <jats:italic>S. aureus, L. monocytogenes<\/jats:italic>\n                    , and\n                    <jats:italic>C. albicans<\/jats:italic>\n                    being the most susceptible. The compounds inhibited violacein synthesis in\n                    <jats:italic>Chromobacterium violaceum<\/jats:italic>\n                    CV12472 and MIC and sub\u2010MIC concentrations.\n                    <jats:bold>AT10a<\/jats:bold>\n                    and\n                    <jats:bold>AT11a<\/jats:bold>\n                    all showed 100% inhibition at MIC and 1\/2 MIC concentrations, whereas compound\n                    <jats:bold>AT10b<\/jats:bold>\n                    and compound\n                    <jats:bold>AT11b<\/jats:bold>\n                    had 85.1%\u00a0\u00b1\u00a02.1% and 90.7%\u00a0\u00b1\u00a01.2% inhibitions at 1\/2 MIC. The compounds inhibited quorum sensing (QS) against\n                    <jats:italic>C. violaceum<\/jats:italic>\n                    CV026 at MIC and 1\/2 MIC, with\n                    <jats:bold>AT11a<\/jats:bold>\n                    being the most active with inhibition diameters of 18.50\u00a0\u00b1\u00a00.75\u00a0mm (MIC) and 11.50\u00a0\u00b1\u00a00.47\u00a0mm (1\/2 MIC). QS inhibition indicates that the compounds could disrupt communication and coordinated behavior in bacteria. The compounds inhibited swarming and swimming motilities against\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    PA01 at MIC and sub\u2010MIC concentrations, implying that they can reduce spread of bacteria and cross\u2010infections through surface colonization. The compounds showed concentration\u2010dependent biofilm inhibition against a range of pathogenic bacteria at MIC and sub\u2010MIC.\n                    <jats:italic>S. aureus, L. monocytogenes<\/jats:italic>\n                    , and\n                    <jats:italic>S. typhi<\/jats:italic>\n                    biofilms were most susceptible to the compounds compared to the others. Inhibition of biofilm is an indication of possible eradication of resistance in bacteria. The results suggest that triazole\u2010based calixarene derivatives are suitable scaffolds for the development of good AMs, which could quench cell\u2010to\u2010cell signaling and attenuate virulence factors in bacteria.\n                  <\/jats:p>","DOI":"10.1002\/bab.2761","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T06:45:01Z","timestamp":1744958701000},"page":"1546-1559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Design and Synthesis of Triazole\u2010Based\n                    <i>p<\/i>\n                    \u2010\n                    <i>tert<\/i>\n                    \u2010Butylcalix[4]Arene Conjugates and Evaluation of Their Antimicrobial, Antibiofilm, and Anti\u2010Quorum\u2010Sensing Activities"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6683-3337","authenticated-orcid":false,"given":"Alfred Ngenge","family":"Tamfu","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, School of Chemical Engineering and Mineral Industries University of Ngaoundere  Ngaoundere Cameroon"},{"name":"Vocational School of Health Services Usak University  Usak Turkey"},{"name":"Food Quality Control and Analysis Program, Ula Ali Kocman Vocational School Mugla Sitki Ko\u00e7man University  Ula Mugla Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9147-5938","authenticated-orcid":false,"given":"Selahattin","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Vocational School of Health Services Usak University  Usak Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1865-1093","authenticated-orcid":false,"given":"Ozgur","family":"Ceylan","sequence":"additional","affiliation":[{"name":"Food Quality Control and Analysis Program, Ula Ali Kocman Vocational School Mugla Sitki Ko\u00e7man University  Ula Mugla Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564\u2010019\u20100565\u20108"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27154872"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens12010116"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.53631"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bab.2545"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)02724\u20100"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.130042"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25215024"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3897\/pharmacia.69.e87834"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2022.114162"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24173152"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2014.0557"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2023.136262"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.676458"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.99"},{"key":"e_1_2_8_17_1","first-page":"91","article-title":"Bacterial Resistance to Antibiotics: The Role of Biofilms","volume":"37","author":"Hoyle B. 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