{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T10:12:19Z","timestamp":1768731139721,"version":"3.49.0"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T00:00:00Z","timestamp":1751760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biotech and App Biochem"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Zearalenone (ZEN) is a prevalent immunosuppressive and estrogenic metabolite synthesized by certain species of\n                    <jats:italic>Fusarium<\/jats:italic>\n                    fungi. This mycotoxin has a propensity to contaminate food and feed products, leading to immune system suppression and reproductive disorders. Therefore, the mitigation of ZEN production and the amelioration of its toxic effects are critical components in the management of ZEN contamination. This study aims to evaluate the\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    cocktail as a potential probiotic to reduce the toxicity of ZEN in mice receiving ZEN\u2010contaminated food. Twenty\u2010four mice were randomly divided into three groups for the study. The control group (T1) received a standard diet, whereas Groups T2 and T3 were given diets contaminated with ZEN at 10\u00a0\u00b5g\/g. Additionally, Group T3 received a\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    cocktail at 10\n                    <jats:sup>9\u00a0<\/jats:sup>\n                    colony\u2010forming units (cfu)\/g. ZEN levels were confirmed using liquid chromatography\u2013mass spectrometry (LC\u2013MS). On Day 28, the mice were sacrificed, and blood, liver, and ileum samples were analyzed. According to the findings, the\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    cocktail effectively decreased the ZEN concentration in vitro by up to 64.5% (\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    &lt;\u00a00.05). Mice that consumed a meal contaminated with ZEN showed impairment in their daily weight, food intake, liver enzyme, lipid peroxidation, intestinal morphometric traits, and gene expression. Dietary inclusion of\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    cocktail as a potential probiotic significantly improved these parameters (\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    &lt;\u00a00.05). The\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    cocktail likely mitigated the toxic effects of ZEN by enhancing immune responses, improving antioxidant capacity, and reducing the bioavailability of ZEN in the intestine through non\u2010covalent binding to the toxin.\n                  <\/jats:p>","DOI":"10.1002\/bab.2782","type":"journal-article","created":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T10:36:23Z","timestamp":1751798183000},"page":"1763-1770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Lactobacillus<\/i>\n                    Cocktail Potentially Alleviated the Toxic Effects of Zearalenone in Mice Receiving a Zearalenone\u2010Contaminated Diet"],"prefix":"10.1002","volume":"72","author":[{"given":"Delaram","family":"Hassani","sequence":"first","affiliation":[{"name":"Department of Biology, Ma. C. Islamic Azad University Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Golnar","family":"Kermani","sequence":"additional","affiliation":[{"name":"Department of Biology, Ma. C. Islamic Azad University Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh Samizadeh","family":"Mashhadi","sequence":"additional","affiliation":[{"name":"Department of Biology, Ma. C. Islamic Azad University Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behnoosh","family":"Taghizadegan","sequence":"additional","affiliation":[{"name":"Department of Biology, Ma. C. Islamic Azad University Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayna Moslemian","family":"Abbasabadi","sequence":"additional","affiliation":[{"name":"Department of Biology, Ma. C. Islamic Azad University Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Negin","family":"Shafaei","sequence":"additional","affiliation":[{"name":"Department of Biology, Ma. C. Islamic Azad University Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5011-9611","authenticated-orcid":false,"given":"Ehsan","family":"Karimi","sequence":"additional","affiliation":[{"name":"Department of Biology, Ma. C. 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