{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T14:06:44Z","timestamp":1765289204626,"version":"3.46.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biotech and App Biochem"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Multiple sclerosis (MS) is an autoimmune condition affecting the central nervous system (CNS), resulting in immune\u2010mediated demyelination and neurodegeneration. The NF\u2010\u03baB signaling pathway is pivotal in the inflammatory processes that drive MS pathogenesis. Recent research has underscored the therapeutic potential of peptides owing to their low immunogenicity, high specificity, and minimal side effects. PB1\u2010F2, a protein from the influenza virus, has shown the capacity to modulate inflammation by inhibiting the NF\u2010\u03baB pathway. Synthetic peptides were designed on the basis of the C\u2010terminal region of PB1\u2010F2 and evaluated for their ability to suppress NF\u2010\u03baB\u2010mediated inflammatory responses. Among these peptides, RZV8 emerged as the most potent peptide and was selected for further investigation. This study aimed to explore the therapeutic effects of the intraperitoneal administration of RZV8 in experimental autoimmune encephalomyelitis (EAE), an animal model of MS. Following EAE induction in female C57BL\/6J mice, the animals were treated with RZV8. Various serum inflammatory mediators, motor functions, myelination, and inflammatory cell infiltration levels were then assessed. Our results demonstrated that RZV8 administration alleviated EAE clinical severity, reducing inflammation, demyelination, and gliosis in EAE mice. We propose that the therapeutic effects of RZV8 are primarily due to its neuroprotective and anti\u2010inflammatory properties. These results could offer new perspectives for treating neuroinflammatory diseases, such as MS, highlighting RZV8 as a potential therapeutic candidate.<\/jats:p>","DOI":"10.1002\/bab.2790","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T06:50:04Z","timestamp":1748415004000},"page":"1835-1844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of PB1\u2010F2 Protein\u2010Derived Peptide Effects on Clinical Symptoms and Inflammatory Factors in an Animal Model of Multiple Sclerosis"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6601-0302","authenticated-orcid":false,"given":"Seyed Hossein","family":"Khatami","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine Baqiyatallah University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Karima","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, School of Medicine Shahid Beheshti University of Medical Sciences (SBMU)  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahman Jalali","family":"Kondori","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences, Faculty of Medicine Baqiyatallah University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mojtaba","family":"Sepandi","sequence":"additional","affiliation":[{"name":"Health Research Center, Life Style Institute Baqiyatallah University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohreh","family":"Jangravi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine Baqiyatallah University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028936"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562864211007687"},{"issue":"1","key":"e_1_2_11_4_1","first-page":"1","article-title":"Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell\u2010Based Therapy","volume":"19","author":"Ghasemi N.","year":"2017","journal-title":"Cell Journal (Yakhteh)"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-023-12140-z"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000319"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2016-001381"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000037297"},{"key":"e_1_2_11_9_1","first-page":"41","volume-title":"NF\u2010\u03baB, an Evolutionarily Conserved Mediator of Immune and Inflammatory Responses. 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