{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:08:51Z","timestamp":1787782131127,"version":"build-2784847793"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biotech and App Biochem"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chronic inflammation triggered by viral infections poses significant challenges to human health. This study aims to evaluate the potential of ZINC\u2010592, a novel Keap1 inhibitor, in mitigating chronic inflammation associated with viral infections mediated by IgE. High\u2010throughput screening, molecular docking studies, and molecular dynamics simulations were employed. RBL\u20102H3 cells and human whole blood basophils were used to evaluate the IgE\u2010mediated anti\u2010inflammatory effects. Molecular docking analysis revealed favorable binding interactions between the lead compound ZINC\u2010592 and Keap1, suggesting its potential as a Keap1 inhibitor. Molecular dynamics simulations confirmed the stability of the ZINC\u2010592\u2013Keap1 complex over time. In vitro assays demonstrated that ZINC\u2010592 effectively suppressed IgE\u2010sensitized RBL\u20102H3 degranulation and proinflammatory cytokine production in these cells. The compound dose\u2010dependently inhibited CD63 in IgE\u2010Fc\u03b5RI\u2010stimulated basophils. Keap1 and Nrf2\u2010positive populations were decreased upon ZINC\u2010592 treatment in IgE\u2010stimulated RBL\u20102H3 cells. The findings of this study highlight the promising therapeutic potential of ZINC\u2010592 as a Keap1 inhibitor for mitigating chronic inflammation associated with viral infections, including those exacerbated by IgE\u2010mediated immune responses. Further preclinical and clinical investigations are warranted to develop ZINC\u2010592 as a novel therapeutic agent for viral infection\u2010induced inflammation, particularly in the context of IgE\u2010mediated immune responses.<\/jats:p>","DOI":"10.1002\/bab.70037","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T07:07:44Z","timestamp":1755068864000},"page":"455-465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["ZINC\u2010592 Ameliorates IgE\u2010Mediated Chronic Inflammatory Responses of Viral Infections via Keap1\/Nrf2 Signaling"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7994-7130","authenticated-orcid":false,"given":"Ashish","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Microbiology &amp; Clinical Parasitology, College of Medicine King Khalid University  Abha Saudi 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