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The National Programme currently recommends quinine\u2010 and artemisinin\u2010based combination therapy (ACT) for the treatment of severe malaria. However, the growing resistance to these treatments highlights the urgent need for alternative therapeutic strategies. A key factor in cerebral malaria pathophysiology is\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    erythrocyte membrane protein 1 (\n                    <jats:italic>Pf<\/jats:italic>\n                    EMP1), which facilitates the sequestration of infected red blood cells in the microvasculature. Targeting\n                    <jats:italic>Pf<\/jats:italic>\n                    EMP1 represents a promising approach for therapeutic interventions. This study uses a multi\u2010modal computational approach to identify FDA\u2010approved drugs that could be repurposed to target\n                    <jats:italic>Pf<\/jats:italic>\n                    EMP1. Among the top candidate molecules are Lumacaftor, Vilazodone, Tucatinib, Lenvatinib, and Hydrocortisone Cypionate, which exhibit favorable docking energies (\u22129.1 to \u22128.3\u00a0kcal\/mol) and potential oral bioavailability, as determined by receptor\u2010based screening and absorbed, distributed, metabolized, and eliminated (ADME) analysis. Molecular dynamics simulations confirm stable interactions between these drug molecules and\n                    <jats:italic>Pf<\/jats:italic>\n                    EMP1, supported by favorable potential energy profiles and structural stability. Additionally, protein\u2013ligand interaction analysis identifies key residues involved in drug binding, providing insights into their molecular effectiveness. Gibbs's free energy landscape analysis further reinforces the stability of these drug\u2013protein complexes, underscoring their potential as therapeutic agents. These findings highlight the significant role of computational approaches in drug discovery and offer valuable insights into repurposing FDA\u2010approved drugs for cerebral malaria treatment.\n                  <\/jats:p>","DOI":"10.1002\/bab.70040","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T05:57:12Z","timestamp":1755151032000},"page":"488-512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Computational Drug Repositioning for Targeting\n                    <i>Pf<\/i>\n                    EMP1: Potential Therapeutics for Cerebral Malaria in\n                    <i>Plasmodium falciparum<\/i>"],"prefix":"10.1002","volume":"73","author":[{"given":"Kanika","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Molecular Epidemiology National Institute of Malaria Research  Delhi 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