{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:53:37Z","timestamp":1788836017636,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biotech and App Biochem"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ethanol generated during yeast fermentation has potential oxidative damaging effects, which can induce yeast aging and death. It has been reported that water extract of\n                    <jats:italic>Ligusticum chuanxiong<\/jats:italic>\n                    Hort (Lch) exhibits antiaging effects on\n                    <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n                    . However, the role and underlying mechanisms of Lch in\n                    <jats:italic>S. cerevisiae<\/jats:italic>\n                    under ethanol stress remain elusive. Herein, we showed that Lch significantly improves the survival of\n                    <jats:italic>S. cerevisiae<\/jats:italic>\n                    under ethanol stress. Transcriptome analysis revealed that carbohydrate metabolism, amino acid metabolism, and ribosome biogenesis pathways were enriched in ethanol\u2010treated\n                    <jats:italic>S. cerevisiae<\/jats:italic>\n                    . Compared with ethanol treatment, ribosome biogenesis and RNA polymerase pathways were enriched in Lch and ethanol co\u2010treated\n                    <jats:italic>S. cerevisiae<\/jats:italic>\n                    . Additionally, glutathione (GSH) metabolism pathway was exclusively enriched in\n                    <jats:italic>S. cerevisiae<\/jats:italic>\n                    co\u2010treated with Lch and ethanol. Supplementation with GSH significantly enhanced the survival of ethanol\u2010treated\n                    <jats:italic>S. cerevisiae<\/jats:italic>\n                    . Taken together, these results suggest that Lch protects\n                    <jats:italic>S. cerevisiae<\/jats:italic>\n                    against ethanol stress by modulating ribosome biogenesis and GSH metabolism pathways.\n                  <\/jats:p>","DOI":"10.1002\/bab.70091","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T13:52:02Z","timestamp":1763128322000},"page":"1241-1251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transcriptome Analysis of\n                    <i>Ligusticum chuanxiong<\/i>\n                    Horts Extract on Yeast Aging Under Ethanol Stress"],"prefix":"10.1002","volume":"73","author":[{"given":"Zaoya","family":"Zhao","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory of Green Processing of Sugar Resources College of Biological and Chemical Engineering Guangxi University of Science and Technology  Liuzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luchen","family":"Xu","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Green Processing of Sugar Resources College of Biological and Chemical Engineering Guangxi University of Science and Technology  Liuzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjin","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Green Processing of Sugar Resources College of Biological and Chemical Engineering Guangxi University of Science and Technology  Liuzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6653-4318","authenticated-orcid":false,"given":"Jinyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Green Processing of Sugar Resources College of Biological and Chemical Engineering Guangxi University of Science and Technology  Liuzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinhui","family":"Yan","sequence":"additional","affiliation":[{"name":"Daye Public Inspection and Testing Center  Daye P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yi","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Green Processing of Sugar Resources College of Biological and Chemical Engineering Guangxi University of Science and Technology  Liuzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianxing","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Liuzhou People's Hospital Affiliated to Guangxi Medical University  Liuzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.111.135731"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253\u2010009\u20102223\u20101"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253\u2010010\u20102594\u20103"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1042\/BA20090036"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.02.050"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e19027"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c01650"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fm.2020.103713"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253\u2010017\u20108432\u20100"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11274\u2010017\u20102376\u20105"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2019.103377"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00449\u2010008\u20100292\u20107"},{"issue":"2","key":"e_1_2_10_14_1","first-page":"189","article-title":"Ethanol Cellular Defense Induce Unfolded Protein Response in Yeast","volume":"7","author":"Navarro\u2010Tapia E.","year":"2016","journal-title":"Frontiers in Microbiology"},{"issue":"03","key":"e_1_2_10_15_1","first-page":"9","article-title":"Study on the Difference of Glucose and Fructose Utilization During Alcohol Fermentation of Mixed Yeast Strains","volume":"28","author":"Qiongsha H.","year":"2017","journal-title":"Journal of Guangxi University of Technology"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462\u20102920.2010.02317.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mcb.2022.09.006"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115110"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot101691"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp1137"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102105\u201012\u2010323"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010014\u20100550\u20108"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.73"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10295\u2010019\u201002175\u20105"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10123\u2010018\u201000044\u20102"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475\u20102859\u201011\u201098"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.02.011"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1806.06014"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10111735"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiosc.2017.03.009"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep31311"},{"issue":"5","key":"e_1_2_10_33_1","first-page":"383","article-title":"Ethanol Effects Involve Non\u2010Canonical Unfolded Protein Response Activation in Yeast Cells","volume":"8","author":"Navarro\u2010Tapia E.","year":"2017","journal-title":"Frontiers in Microbiology"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13068\u2010018\u20101107\u2010y"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28237895"},{"issue":"4","key":"e_1_2_10_36_1","article-title":"Effect of Ethanol\u2010Derived Clove Leaf Extract on the Oxidative Stress Response in Yeast Schizosaccharomyces pombe","volume":"2019","author":"Fauzya A. F.","year":"2019","journal-title":"International Journal of Microbiology"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2015.02.031"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8205983"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-022-03155-7"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114333"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2010.11.014"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201004295\u20104"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-022-08187-2"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2006.11.002"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13712"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/15.24.10133"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.822864"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8010043"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/fermentation11020047"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-019-2762-2"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12033\u2010018\u20100087\u20102"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968\u20100004(96)20011\u20108"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.03.006"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00292\u201014"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glac135"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.003483"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.02.028"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418\u2010018\u20100270\u20109"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-017-0868-8"}],"container-title":["Biotechnology and Applied Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bab.70091","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bab.70091","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bab.70091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:47:23Z","timestamp":1781797643000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/bab.70091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,14]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/bab.70091"],"URL":"https:\/\/doi.org\/10.1002\/bab.70091","archive":["Portico"],"relation":{},"ISSN":["0885-4513","1470-8744"],"issn-type":[{"value":"0885-4513","type":"print"},{"value":"1470-8744","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,14]]},"assertion":[{"value":"2024-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}