{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:28:41Z","timestamp":1787506121625,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biotech and App Biochem"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Acute myeloid leukemia (AML) is a rapidly progressing blood cancer with poor survival rates, necessitating aggressive treatment strategies like chemotherapy. Doxorubicin (DOXO) is commonly used but is limited by severe side effects, including myeloablation, which involves the depletion of bone marrow cells leading to immunosuppression and heightened infection risk. This study explores the potential of omega\u20103 polyunsaturated fatty acids (\n                    <jats:italic>n<\/jats:italic>\n                    \u20103 PUFAs), specifically docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), to enhance the efficacy of DOXO against AML cells while mitigating some of its toxicities. The results show that DHA and EPA increase the DOXO\u2010induced apoptosis in KG1a cells and greater accumulation in the sub\u2010G1 phase, suggesting enhanced cell death. TUNEL assays confirmed increased DNA fragmentation, whereas mRNA analysis revealed upregulation of apoptosis and cell cycle regulation genes. Importantly, DHA and EPA also reduced the hemolytic activity of DOXO, suggesting a protective effect against chemotherapy\u2010associated side effects. These findings suggest that DHA and EPA could enhance the anti\u2010leukemic impact of DOXO, potentially reducing the need for high\u2010dose chemotherapy and alleviating risks like myeloablation, offering a promising adjunct strategy for AML treatment.\n                  <\/jats:p>","DOI":"10.1002\/bab.70137","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:49:32Z","timestamp":1769755772000},"page":"1844-1861","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>N<\/i>\n                    \u20103 PUFAs Enhancing Chemotherapy Efficacy in Acute Myeloid Leukemia While Safeguarding Healthy Cells"],"prefix":"10.1002","volume":"73","author":[{"given":"Pradnya","family":"Gurav","sequence":"first","affiliation":[{"name":"School of Bioengineering Sciences and Research MIT Art, Design and Technology University  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna","family":"Sivaram","sequence":"additional","affiliation":[{"name":"School of Bioengineering Sciences and Research MIT Art, Design and Technology University  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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