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In the present study, the inhibitory properties of twelve 1\u2010alkyl\u20101\n                    <jats:italic>H<\/jats:italic>\n                    \u2010benzimidazolium sulfonates and two 1\u2010alkyl\u20101\n                    <jats:italic>H<\/jats:italic>\n                    \u2010benzimidazolium iodides on PPO activity have been investigated. The PPO enzyme was purified from banana using Sepharose 4B\u2010tyrosine\u2010\n                    <jats:italic>p<\/jats:italic>\n                    \u2010aminobenzoic acid affinity gel chromatography. The effects of 14 different synthesized benzimidazole derivatives on the PPO enzyme were investigated, and they were found to significantly inhibit the enzyme in question. When ADME predictions were examined, it was seen that all compounds that include methylbenzenesulfonate structure showed good pharmacokinetic properties; only compounds\n                    <jats:bold>3a<\/jats:bold>\n                    and\n                    <jats:bold>3b<\/jats:bold>\n                    , which contain iodide, violated the Ghose rules. These compounds, which were effective at low concentrations, may serve as promising lead molecules for the development of PPO inhibitors with potential applications in food preservation, cosmetic formulations, and pharmaceutical research, pending further in vivo and formulation\u2010based studies.\n                  <\/jats:p>","DOI":"10.1002\/bab.70145","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T07:28:04Z","timestamp":1771226884000},"page":"805-812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["1\u2010Alkyl\u20101\n                    <i>H<\/i>\n                    \u2010Benzimidazolium Sulfonates as Non\u2010Competitive Inhibitors of Polyphenol Oxidase"],"prefix":"10.1002","volume":"73","author":[{"given":"Adem","family":"Erg\u00fcn","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Arts and Sciences Balikesir University  Balikesir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00fcbra","family":"\u00c7ikrikci","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Arts and Sciences Balikesir University  Balikesir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahit","family":"Gen\u00e7er","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Arts and Sciences Balikesir University  Balikesir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oktay","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Arts and Sciences Balikesir University  Balikesir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harun","family":"Uslu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Firat University  Elaz\u0131\u011f T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00fcnyamin","family":"G\u00f6kta\u015f","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Firat University  Elaz\u0131\u011f T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mert Olgun","family":"Karata\u015f","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Art and Sciences \u0130n\u00f6n\u00fc University  Malatya Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2022.100606"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2023.2253906"},{"key":"e_1_2_8_4_1","first-page":"120","article-title":"Pharmacological Significance of Synthetic Heterocycles Scaffold: A Review","volume":"5","author":"Dua R.","year":"2011","journal-title":"Advances in Biological Research"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.6.1558S"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13065-019-0521-y"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.11.053"},{"key":"e_1_2_8_8_1","first-page":"233","article-title":"Pharmacokinetics of Benzimidazole Derivatives","volume":"48","author":"Spasov A. 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