{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:54:01Z","timestamp":1786118041904,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biotech and App Biochem"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A novel heteropolysaccharide named HEP\u2010S was separated from the mycelium of\n                    <jats:italic>Hericium erinaceus<\/jats:italic>\n                    using hot water extraction. The structure of HEP\u2010S (2.45\u00a0\u00d7\u00a010\n                    <jats:sup>6<\/jats:sup>\n                    \u00a0Da) is mainly composed of \u21924,6)\u2010\u03b1\u2010D\u2010Glc\n                    <jats:italic>p<\/jats:italic>\n                    (1\u2192, \u21922)\u2010\u03b1\u2010D\u2010Man\n                    <jats:italic>p<\/jats:italic>\n                    (1\u2192, \u21924)\u2010\u03b1\u2010D\u2010Glc\n                    <jats:italic>p<\/jats:italic>\n                    (1\u2192, \u21923,6)\u2010\u03b2\u2010D\u2010Glc\n                    <jats:italic>p<\/jats:italic>\n                    (1\u2192, T\u2010\u03b2\u2010D\u2010Gal\n                    <jats:italic>p<\/jats:italic>\n                    (1\u2192, and \u21924)\u2010\u03b2\u2010D\u2010Gal\n                    <jats:italic>p<\/jats:italic>\n                    (1\u2192. In addition, we investigated the anti\u2010inflammatory activity and mechanism of HEP\u2010S in lipopolysaccharide\u2010stimulated RAW264.7 cells. HEP\u2010S (20, 40, and 80\u00a0\u00b5g\/mL) could suppress the production of inflammatory cytokines by reducing vital transcription factors in the nuclear factor\u2010\u03baB signaling (NF\u2010\u03baB) pathway. The results showed that HEP\u2010S exhibited notable anti\u2010inflammatory activity on RAW 264.7, demonstrating its potential therapeutic effect on relieving gastritis.\n                  <\/jats:p>","DOI":"10.1002\/bab.70148","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T07:17:24Z","timestamp":1777015044000},"page":"1975-1987","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural Characterization and Anti\u2010Inflammatory Activities of Polysaccharide From\n                    <i>Hericium erinaceus<\/i>\n                    Mycelium"],"prefix":"10.1002","volume":"73","author":[{"given":"Chong","family":"Sun","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Food Quality and Health Tianjin University of Science and Technology  Tianjin People's Republic of China"},{"name":"State Key Laboratory of Food Nutrition and Safety Tianjin University of Science 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