{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:55:03Z","timestamp":1786118103219,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biotech and App Biochem"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The emergence of drug\u2010resistant microorganisms and the need for effective anticancer agents necessitate the development of novel nanomaterials with enhanced biomedical performance. This study aims to synthesize barium and iron dual\u2010doped titanium dioxide (TiBaFeO NC) using a green precipitation method with\n                    <jats:italic>Psidium guajava<\/jats:italic>\n                    leaf extract, targeting improved antimicrobial and anticancer efficacy. The synthesized nanocomposite was characterized by various analytical techniques. XRD confirmed the crystalline anatase phase of TiO\n                    <jats:sub>2<\/jats:sub>\n                    and TiBaFeO NC, with average crystallite sizes of 40 and 37\u00a0nm, respectively, suitable for biomedical applications. UV\u2010Vis analysis showed a decrease in bandgap from 3.79\u00a0eV for TiO\n                    <jats:sub>2<\/jats:sub>\n                    to 3.67\u00a0eV for TiBaFeO NC, indicating enhanced reactive oxygen species (ROS) generation potential. PL spectra exhibited green emissions at 520\u00a0nm for TiO\n                    <jats:sub>2<\/jats:sub>\n                    and 523\u00a0nm for TiBaFeO NC, reflecting a higher oxygen vacancy defect density in the doped nanocomposite. Biological evaluations demonstrated that TiBaFeO NC exhibited superior antimicrobial activity against Gram\u2010positive bacteria (\n                    <jats:italic>Staphylococcus aureus, Bacillus subtilis, Bacillus megaterium<\/jats:italic>\n                    ), Gram\u2010negative bacteria (\n                    <jats:italic>Shigella dysenteriae, Escherichia coli, Proteus vulgaris<\/jats:italic>\n                    ), and fungi (\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    ). Furthermore, TiBaFeO NC showed enhanced anticancer activity against human breast cancer cells (MDA\u2010MB\u2010231) with an IC\n                    <jats:sub>50<\/jats:sub>\n                    of 9.8\u00a0\u00b5g\/mL, outperforming TiO\n                    <jats:sub>2<\/jats:sub>\n                    . These results suggest that TiBaFeO NC is a promising nanocomposite for advanced biomedical applications, combining enhanced antimicrobial and anticancer properties through defect\u2010mediated ROS generation.\n                  <\/jats:p>","DOI":"10.1002\/bab.70155","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T03:39:53Z","timestamp":1775533193000},"page":"2068-2078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biocidal Activity of Barium and Iron\u2010Co\u2010Doped Titanium Dioxide Nanocomposites, Synthesized by\n                    <i>Psidium guajava<\/i>\n                    \u2010Mediated Precipitation Method"],"prefix":"10.1002","volume":"73","author":[{"given":"Saumya","family":"Goyal","sequence":"first","affiliation":[{"name":"Quantum University Research Center, Quantum University  Roorkee Uttarakhand 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