{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:51:19Z","timestamp":1791874279370,"version":"4.3.4"},"reference-count":84,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biotech and App Biochem"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Dunaliella<\/jats:italic>\n                    species are among the most significant biological sources of carotenoids, notably beta\u2010carotene. Given that chemical synthesis offers a more cost\u2010effective alternative to biotechnological cultivation, optimizing production strategies is essential for economic viability. This study investigated the optimization of bioproduct synthesis in a Brazilian strain of\n                    <jats:italic>Dunaliella salina<\/jats:italic>\n                    by evaluating the effects of high photon flux density (PFD) and temperature under low\u2010salinity conditions (1\u00a0mol\u00a0L\n                    <jats:sup>\u22121<\/jats:sup>\n                    NaCl) to facilitate downstream processing. Batch cultivations were conducted at 26\u00b0C across a PFD gradient ranging from 100 to 2000\u00a0\u00b5mol photons m\n                    <jats:sup>\u22122<\/jats:sup>\n                    \u00a0s\n                    <jats:sup>\u22121<\/jats:sup>\n                    , with additional cultivations performed at 30\u00b0C under maximum irradiance. The results demonstrated that increasing PFD to 2000\u00a0\u00b5mol photons m\n                    <jats:sup>\u22122<\/jats:sup>\n                    \u00a0s\n                    <jats:sup>\u22121<\/jats:sup>\n                    significantly enhanced metabolic performance, yielding a 25% increase in biomass concentration, a 62% rise in biomass productivity, and an 82% surge in total carotenoid production. Furthermore, carbohydrate content increased by 61%, whereas lipid levels remained stable, exhibiting a fatty acid profile conducive to biodiesel production. The temperature variation up to 30\u00b0C had no effect on biomass concentration or biomass composition, affecting only the fatty acid composition. These findings underscore the robust potential of this strain for the large\u2010scale biotechnological production of carotenoids and other high\u2010value compounds within a biorefinery framework.\n                  <\/jats:p>","DOI":"10.1002\/bab.70215","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:16:48Z","timestamp":1791458208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potential for Carotenoid and Other Bioproducts Production by a Brazilian\n                    <i>Dunaliella salina<\/i>\n                    Isolate Using a High Photon Flux Density Strategy"],"prefix":"10.1002","author":[{"given":"Camylle Guimar\u00e3es","family":"Scheliga","sequence":"first","affiliation":[{"name":"Laboratory of Microalgal Biotechnology, Chemistry and Biotechnology Division National Institute of Technology  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela Queiroz","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Microalgal Biotechnology, Chemistry and Biotechnology Division National Institute of Technology  Rio de Janeiro Rio de Janeiro Brazil"},{"name":"Laboratory of Biotechnology, School of Chemistry and Food Federal University of Rio Grande  Rio Grande Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucielen Oliveira","family":"Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology, School of Chemistry and Food Federal University of Rio Grande  Rio Grande Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia Maria Luz Lapa","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Laboratory of Microalgal Biotechnology, Chemistry and Biotechnology Division National Institute of Technology  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2023.103047"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.59324\/EJMHR.2025.3(1).05"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201007540\u2010x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpy.13173"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2018.08.035"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e18507"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.HELIYON.2023.E18685"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13213\u2010020\u201001588\u20103"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168819"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jece.2025.115986"},{"key":"e_1_2_9_12_1","volume-title":"Encontro de Pesquisa e Inova\u00e7\u00e3o da Embrapa Agroenergia","author":"Viana N. 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