{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:50:28Z","timestamp":1787169028039,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T00:00:00Z","timestamp":1655510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Bladder pain syndrome (BPS)\/interstitial cystitis (IC) is a debilitating condition characterised by bladder\/pelvic pain and pressure as well as persistent or recurrent urinary symptoms in the absence of an identifiable cause. It is hypothesised that in addition to organ specific visceral hypersensitivity, contributions of the hypertonic pelvic floor, peripheral sensitisation, and central sensitisation exacerbate this condition. The aim of this paper is to investigate outcomes of treating underlying neuromuscular dysfunction and neuro\u2010plastic mechanisms in BPS\/IC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective chart review of 84 patients referred to an outpatient pelvic rehabilitation centre with a diagnosis of BPS\/IC given to them by a urologist. All 84 patients failed to progress after completing 6\u2009weeks of pelvic floor physical therapy and underwent an institutional review board approved protocol (IRB# 17\u20100761) consisting of external ultrasound\u2010guided trigger point injections to the pelvic floor musculature, peripheral nerve blocks of the pudendal and posterior femoral cutaneous nerves and continued pelvic floor physical therapy once weekly for 6\u00a0weeks. Pelvic pain intensity and functionality were measured pretreatment and 3\u00a0months posttreatment using Visual Analogue Scale (VAS) and Functional Pelvic Pain Scale (FPPS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pretreatment, mean VAS was 6.23\u2009\u00b1\u20092.68 (95% CI 5.65 to 6.80). Posttreatment mean VAS was 3.90\u2009\u00b1\u20092.63 (95% CI 3.07\u20134.74). Mean FPPS before treatment was 11.98\u2009\u00b1\u20096.28 (95% CI 10.63 to 13.32). Posttreatment mean FPPS was 7.68\u2009\u00b1\u20095.73 (95% CI 6.45\u20138.90). Analysis of subcategories within FPPS indicated highest statistically significant improvement in the categories of bladder, intercourse and working.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Analysis suggests the treatment was effective at ameliorating bladder pain and function including urinary urgency, frequency, and burning in BPS\/IC patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.176","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T06:54:07Z","timestamp":1655535247000},"page":"450-457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Bladder pain syndrome\/interstitial cystitis response to nerve blocks and trigger point injections"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4666-2782","authenticated-orcid":false,"given":"Soha","family":"Patil","sequence":"first","affiliation":[{"name":"Pelvic Rehabilitation Medicine Clinical Research Foundation  West Palm Beach FL USA"},{"name":"The Feinstein Institute for Medical Research Northwell Health  Manhasset NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Daniel","sequence":"additional","affiliation":[{"name":"Pelvic Rehabilitation Medicine Clinical Research Foundation  West Palm Beach FL USA"},{"name":"The Feinstein Institute for Medical Research Northwell Health  Manhasset NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogita","family":"Tailor","sequence":"additional","affiliation":[{"name":"Pelvic Rehabilitation Medicine Clinical Research Foundation  West Palm Beach FL USA"},{"name":"The Feinstein Institute for Medical Research Northwell Health  Manhasset NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Mamsaang","sequence":"additional","affiliation":[{"name":"Pelvic Rehabilitation Medicine Clinical Research Foundation  West Palm Beach FL USA"},{"name":"The Feinstein Institute for Medical Research Northwell Health  Manhasset NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janaki","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Pelvic Rehabilitation Medicine Clinical Research Foundation  West Palm Beach FL USA"},{"name":"The Feinstein Institute for Medical Research Northwell Health  Manhasset NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Moody","sequence":"additional","affiliation":[{"name":"Pelvic Rehabilitation Medicine Clinical Research Foundation  West Palm Beach FL USA"},{"name":"The Feinstein Institute for Medical Research Northwell Health  Manhasset NY 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