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However, this technique leaves the majority of patients of both sexes with poor sexual and urinary function. Organ\u2010sparing cystectomy (OSC) techniques are emerging as an alternative to the standard procedure to preserve these functions, without compromising the oncological outcomes. We present a systematic review and meta\u2010analysis of the published literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MEDLINE, Embase and Web of Science were systematically searched for eligible studies on 6 April 2021. Primary outcomes studied were both oncological outcomes, specifically overall recurrence, and functional outcomes, specifically sexual function, and daytime and nighttime continence. Odds ratios (OR) with 95% confidence intervals (95% CI) were calculated. The PROSPERO registration reference number was CRD42018118897.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 13\u2009894 identified abstracts, 19 studies (1886 male and 305 female patients) were eligible for inclusion in this review. These studies included patients who underwent either whole prostate, prostate capsule, seminal vesicle, nerve, uterus, ovary, vagina and fallopian tube sparing techniques. Four studies included only female patients.<\/jats:p><jats:p>Thirteen studies reported oncological outcomes, and overall recurrence rate was similar between the two groups (five studies; OR 0.73; 95% CI 0.38\u20131.40, <jats:italic>p<\/jats:italic>\u00a0=\u20090.34). Thirteen studies reported on male sexual function. In men, OSC had significantly greater odds of retaining potency (five studies; OR 9.05; 95% CI 5.07\u201316.16, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.00001). Fourteen studies (13 on males and 1 female) reported urinary outcomes. In men, OSC demonstrated greater odds of daytime (seven studies; OR 2.61; 95% CI 1.74 to 3.92, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.00001) and nighttime continence (seven studies; OR 2.62; 95% CI 1.76 to 3.89, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.00001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In carefully selected patients, OSC allows the potential to provide better sexual and urinary function without compromising oncological outcomes. There remains, however, a paucity of OSC studies in females. Further studies are required to make recommendations based on robust clinical evidence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bco2.189","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T05:51:47Z","timestamp":1664776307000},"page":"135-155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Oncological and functional outcomes of organ\u2010preserving cystectomy versus standard radical cystectomy: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4034-1868","authenticated-orcid":false,"given":"Reece","family":"Clay","sequence":"first","affiliation":[{"name":"GKT School of Medical Education King's College London  London UK"},{"name":"William Harvey Hospital East Kent Hospital University Foundation Trust  Kent UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9919-0649","authenticated-orcid":false,"given":"Raghav","family":"Shaunak","sequence":"additional","affiliation":[{"name":"GKT School of Medical Education King's College London  London UK"},{"name":"St Peter's Hospital Ashford and St Peter's Hospital NHS Trust  Chertsey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6341-6615","authenticated-orcid":false,"given":"Siddarth","family":"Raj","sequence":"additional","affiliation":[{"name":"GKT School of Medical Education King's College London  London UK"},{"name":"University Hospital University Hospitals Coventry and Warwickshire NHS Trust  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7246-3651","authenticated-orcid":false,"given":"Alexander","family":"Light","sequence":"additional","affiliation":[{"name":"Imperial College London  London UK"},{"name":"Department of Surgery and Cancer Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Malde","sequence":"additional","affiliation":[{"name":"The Urology Centre, Guy's and St. Thomas' NHS Foundation Trust Guy's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Thurairaja","sequence":"additional","affiliation":[{"name":"The Urology Centre, Guy's and St. Thomas' NHS Foundation Trust Guy's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oussama","family":"El\u2010Hage","sequence":"additional","affiliation":[{"name":"The Urology Centre, Guy's and St. Thomas' NHS Foundation Trust Guy's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8690-0445","authenticated-orcid":false,"given":"Prokar","family":"Dasgupta","sequence":"additional","affiliation":[{"name":"The Urology Centre, Guy's and St. Thomas' NHS Foundation Trust Guy's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed Shamim","family":"Khan","sequence":"additional","affiliation":[{"name":"The Urology Centre, Guy's and St. Thomas' NHS Foundation Trust Guy's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1760-9608","authenticated-orcid":false,"given":"Rajesh","family":"Nair","sequence":"additional","affiliation":[{"name":"The Urology Centre, Guy's and St. Thomas' NHS Foundation Trust Guy's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"WitjesJA BruinsM CathomasR Comp\u00e9ratE CowanNC GakisG et al.EAU guidelines on muscle\u2010invasive and metastatic bladder cancer. 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