{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:42:47Z","timestamp":1789756967408,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Knowledge of factors associated with superior outcomes in women treated with urethral bulking agents for stress urinary incontinence (SUI) remains limited. The aim of this study was to examine associations between post\u2010treatment outcomes in women who had undergone polyacrylamide hydrogel injections for SUI, and physiological and self\u2010reported variables captured during pre\u2010treatment clinical evaluation. A cross\u2010sectional study was undertaken in female patients treated for SUI with polyacrylamide hydrogel injections by a single urologist between January 2012 and December 2019. Post\u2010treatment outcome data were gathered in July 2020 using the Patient Global Impression of Improvement (PGI\u2010I), Urinary Distress Inventory\u2010short form (UDI\u20106), Incontinence Impact Questionnaire (IIQ7), and International Consultation on Incontinence Questionnaire Short Form (ICIQ SF). All other data were gathered from women's medical records including pre\u2010treatment patient\u2010reported outcomes. Associations between post\u2010treatment outcomes and pre\u2010treatment physiological and self\u2010reported variables were investigated using regression models. One hundred seven of the 123 eligible patients completed post\u2010treatment patient\u2010reported outcome measures. Mean age was 63.1\u2009years (range 25\u201393\u2009years), and median time between first injection and follow\u2010up was 51\u2009months (inter\u2010quartile range 23.5\u201370\u2009months). Fifty\u2010five (51%) women had a successful outcome based on PGI\u2010I scores. Women with type 3 urethral hypermobility pre\u2010treatment were more likely to report treatment success (PGI\u2010I). Poor bladder compliance pre\u2010treatment was associated with greater urinary distress, frequency and severity (UDI\u20106 and ICIQ) post\u2010treatment. Older age was associated with worse urinary frequency and severity (ICIQ) post\u2010treatment. Associations between patient\u2010reported outcomes and time between first injection and follow\u2010up were trivial and not statistically significant. Severity of pre\u2010treatment incontinence impact (IIQ\u20107) was associated with worse incontinence impact post\u2010treatment. Type 3 urethral hypermobility was associated with a successful outcome, whereas pre\u2010treatment incontinence impact, poor bladder compliance and older age were associated with poorer self\u2010reported outcomes. Long\u2010term efficacy appears to hold in those who responded to initial treatment.<\/jats:p>","DOI":"10.1002\/bco2.218","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T04:39:10Z","timestamp":1674621550000},"page":"269-276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Factors associated with polyacrylamide hydrogel outcomes in women with stress urinary incontinence"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2717-9085","authenticated-orcid":false,"given":"Venetia","family":"Hoe","sequence":"first","affiliation":[{"name":"Department of Urology Western Health  Footscray Victoria Australia"},{"name":"Department of Surgery The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry H.","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Urology Western Health  Footscray Victoria Australia"},{"name":"Department of Surgery The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla","family":"Gough","sequence":"additional","affiliation":[{"name":"Department of Health Services Research Peter MacCallum Cancer Centre  Melbourne Victoria Australia"},{"name":"Department of Nursing The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen E.","family":"O'Connell","sequence":"additional","affiliation":[{"name":"Department of Urology Western Health  Footscray Victoria Australia"},{"name":"Department of Surgery The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003881.pub4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)35806-8"},{"issue":"1","key":"e_1_2_9_4_1","first-page":"7","article-title":"Diagnosis and treatment of intrinsic sphincter deficiency","volume":"2","author":"McGuire EJ","year":"1995","journal-title":"Int J Urol"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24696"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.06.061"},{"key":"e_1_2_9_7_1","unstructured":"BurkhardFC BoschJ CruzF et al.EAU guidelines on urinary incontinence. 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