{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:51:07Z","timestamp":1781189467872,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the feasibility of loco\u2010regional anaesthesia and to compare perioperative outcomes between loco\u2010regional and standard general anaesthesia in patients with bladder cancer undergoing open radical cystectomy (ORC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>A single\u2010surgeon cohort of 60 consecutive patients with bladder cancer undergoing ORC with an enhanced recovery after surgery protocol between May 2020 and December 2021 was analysed. A study group of 15 patients operated on under combined spinal and epidural anaesthesia was compared with a control group of 45 patients receiving standard general anaesthesia. Intraoperative outcomes were haemodynamic stability, estimated blood loss, intraoperative red blood cell transfusion rate, and anaesthesia time. Postoperative outcomes were pain assessment 24\u2009h after surgery, time to mobilisation, return to oral diet, time to bowel function recovery, length of stay and rate of 90\u2010day complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No patients required conversion from loco\u2010regional to general anaesthesia. All patients in both groups were haemodynamically stable. No significant differences between groups were observed for all other intraoperative outcomes, except for a shorter anaesthesia time in the study versus control group (250 vs. 290\u2009min, <jats:italic>p<\/jats:italic>\u2009=\u20090.01). Pain visual score 24\u2009h after surgery was significantly lower in the study versus control group (0 vs. 2, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). No significant differences were observed for all other postoperative outcomes, with a comparable time to bowel function recovery (5\u00a0days in each group for stool passage), and 90\u2010day complication rate (46.6% vs. 42.2% for the study vs. control group, <jats:italic>p<\/jats:italic>\u2009=\u20090.76).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our exploratory, controlled study confirmed the feasibility, safety and effectiveness of a pure loco\u2010regional anaesthesia in patients with bladder cancer undergoing ORC. No significant differences were observed in intra\u2010 and postoperative outcomes between loco\u2010regional and general anaesthesia, except for a significantly shorter anaesthesia time and greater pain reduction in the early postoperative period for the former.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bco2.221","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T01:26:21Z","timestamp":1696382781000},"page":"101-108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Combined spinal and epidural anaesthesia for open radical cystectomy: A controlled study"],"prefix":"10.1002","volume":"5","author":[{"given":"Maria","family":"Galletta","sequence":"first","affiliation":[{"name":"Gaetano Barresi Department of Human and Paediatric Pathology, Anaesthesiology Section University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"De Pasquale","sequence":"additional","affiliation":[{"name":"Gaetano Barresi Department of Human and Paediatric Pathology, Anaesthesiology Section University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Buttitta","sequence":"additional","affiliation":[{"name":"Gaetano Barresi Department of Human and Paediatric Pathology, Urology Section University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Vigan\u00f2","sequence":"additional","affiliation":[{"name":"Gaetano Barresi Department of Human and Paediatric Pathology, Urology Section University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Mucciardi","sequence":"additional","affiliation":[{"name":"Gaetano Barresi Department of Human and Paediatric Pathology, Urology Section University of Messina  Messina 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