{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:20:18Z","timestamp":1767136818625,"version":"build-2238731810"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic scrotal pain is a common condition with a prevalence of 2.5\u20134.8% in male outpatients. Up to 40% of these patients report depressive symptoms and many feel isolated. Minimal invasive treatment is lacking, while spermatic cord injections of Botox\u00ae (BTX) have been proposed to offer long\u2010term pain relief.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>This research protocol comprises a prospective multicentre, randomized, double\u2010blinded clinical trial drawing patients from other urological departments in the region of Southern Denmark.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>End Points<\/jats:title>\n                    <jats:p>The primary end point will be reduction in pain evaluated by visual analogue score for pain at 3\u00a0months. Secondary end point will be length of effect of BTX injections along with changes in quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>The study will include 50 patients for randomization to either spermatic cord block with 100\u2009IE BTX or sterile saline. All patients will prior to randomization undergo physical examination and will be asked to fulfil multiple questionnaires regarding pain and impact in daily life, that is, (1) visual analogue score for pain, (2) quality of life (EQ\u20105D\u20105L), (3) Chronic Prostatitis Symptom Index (NIH\u2010CPSI), (4) ICD\u201010 depression questionnaire (MDI), (5) Likert global assessment scale, and (6) International Index of Erectile Function questionnaire. Physical examination and fulfilment of the questionnaires will be repeated multiple times throughout the study period of 12\u2009weeks. After this time point, patients will be unblinded, and the control arm will be given the opportunity of cross\u2010over.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.349","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T01:39:50Z","timestamp":1714009190000},"page":"655-661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Botox treatment in patients with chronic scrotal pain: Protocol for a randomized double\u2010blinded control trial"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8335-7280","authenticated-orcid":false,"given":"Nicolai Skov","family":"Schiellerup","sequence":"first","affiliation":[{"name":"Department of Urology Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanne","family":"Kobber\u00f8","sequence":"additional","affiliation":[{"name":"Department of Urology Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Urology Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte Aaberg","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Urology Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7622-8402","authenticated-orcid":false,"given":"Mads Hvid","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Urology Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2017.05.23"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12262-008-0032-x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.57.8.697"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/24740527.2017.1328592"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.5326"},{"key":"e_1_2_11_7_1","volume-title":"Chronic testicular pain","author":"Leslie SW","year":"2020"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2017.03.03"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.5238"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2012.02937.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1042\/NS20180058"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3344\/kjp.2011.24.1.1"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-70942009000300013"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007533.pub2"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-005-0035-0"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.43.7s.3.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.60343"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpuro1124"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-4388(94)90053-1"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12707"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000658"},{"key":"e_1_2_11_22_1","unstructured":"D.Engeler(Chair) APBananowski B.Berghmanset al.Chronic pelvic pain [Guideline]. European Association of Urology: European Association of Urology 2022[updated March 2022]. 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