{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:15:50Z","timestamp":1778739350761,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to investigate the impact of risk group classification, restaging transurethral resection (re\u2010TURBT), and adjuvant treatment intensity on recurrence and progression risks in high\u2010grade Ta tumours in patients with non\u2010muscle invasive bladder cancer (NMIBC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Data from a comprehensive bladder cancer database were utilized for this study. Patients with primary high\u2010grade Ta tumours were included. Risk groups were classified according to AUA\/SUO criteria. Tumour characteristics and patient demographics were analysed using descriptive statistics. Cox proportional hazard regression models were used to assess the effect of re\u2010TURBT and other clinical\/treatment\u2010related predictors on recurrence\u2010 and progression\u2010free survivals. The survivals by selected predictors were estimated using Kaplan\u2013Meier method, and groups were compared by the log\u2010rank test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 218 patients with high\u2010grade Ta bladder cancer, those who underwent re\u2010TURBT had significantly better 5\u2010year recurrence\u2010free survival (71.1% vs. 26.8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.0009) and progression\u2010free survival (98.6% vs. 73%, <jats:italic>p<\/jats:italic>\u2009=\u20090.0018) compared with those with initial TURBT alone. Full BCG treatment (induction and maintenance) showed lower recurrence risk, especially in high\u2010risk patients. However, residual disease at re\u2010TURBT did not significantly affect recurrence risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study highlights the significance of risk group classification, the role of re\u2010TURBT, and the intensity of adjuvant treatment in the management of high\u2010grade Ta tumours. A risk\u2010adapted model is crucial to reduce the burden of unnecessary intravesical treatment and endoscopic procedures.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bco2.363","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T01:09:55Z","timestamp":1713402595000},"page":"913-919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Optimal Management for Primary High Grade Ta Bladder Cancer: Role of re\u2010staging TURBT and Intravesical Adjuvant Therapy"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3505-8232","authenticated-orcid":false,"given":"Tarek","family":"Ajami","sequence":"first","affiliation":[{"name":"Desai Sethi Urology Institute University of Miami Miller School of Medicine  Miami FL United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunwoo","family":"Han","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics Shared Resource Sylvester Comprehensive Cancer Center University of Miami Miller School of Medicine  Miami FL United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9700-0805","authenticated-orcid":false,"given":"Ruben","family":"Blachman\u2010Braun","sequence":"additional","affiliation":[{"name":"Desai Sethi Urology Institute University of Miami Miller School of Medicine  Miami FL United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen Y.","family":"Hougen","sequence":"additional","affiliation":[{"name":"Department of Urology University of Iowa Hospitals and Clinics  Iowa City IA United 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