{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:49:20Z","timestamp":1791841760328,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010344","name":"Aage og Johanne Louis-Hansens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010344","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate risk factors contributing to side\u2010specific benign ureteroenteric strictures following radical cystectomy with an ileal conduit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Data obtained from patients with bladder cancer who underwent radical cystectomy with ileal conduit surgery between 2015 and 2018 were retrospectively analysed. Imaging prior to surgery was analysed, regarding calcifications in the aorta, sarcopenia and postoperatively for length of remaining left ureter. Descriptive analyses were performed on preoperative and perioperative data, comparing patients who developed unilateral left\u2010 or right\u2010sided strictures, bilateral strictures, to those who remained free of strictures. COX regression analysis was employed to calculate crude and adjusted hazard ratio for side\u2010specific strictures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 395 patients. Strictures developed in 19% (75\/395) of the patients, within a median period of 9\u00a0months: 57% (43\/75) unilateral left sided, 20% (15\/75) unilateral right sided and 23% (17\/75) bilateral. Unilateral left\u2010sided stricture was associated with higher body mass index (<jats:italic>p<\/jats:italic>\u2009=\u20090.077) and hypercholesterolemia (<jats:italic>p<\/jats:italic>\u2009=\u20090.007). Right\u2010sided stricture was associated with a history of prior abdominal surgery (<jats:italic>p<\/jats:italic>\u2009=\u20090.029) and postoperative leakage (<jats:italic>p<\/jats:italic>\u2009=\u20090.004). Bilateral stricture was associated with smoking (<jats:italic>p<\/jats:italic>\u2009=\u20090.006) and high BMI (<jats:italic>p<\/jats:italic>\u2009=\u20090.015). The adjusted HR comparing patients with and without previous abdominal surgery was only significantly higher for right\u2010sided ureteroenteric strictures (HR 3.18 [95% CI: 1.11; 9.05]) compared with patients without strictures. No association was identified between strictures and preoperative aortic calcification of the abdominal aorta or sarcopenia as estimated from imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The aetiology of ureteroenteric strictures appears multifactorial. Our findings suggest that development of left\u2010sided stricture is influenced by factors associated with metabolic syndrome, indicating a potential role of distal ureteric ischemia. On the other hand, right\u2010sided stricture was more frequent in patients with previous abdominal surgery and postoperative leakage.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bco2.364","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T00:38:54Z","timestamp":1715042334000},"page":"813-822","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ureteroenteric strictures after cystectomy: Side\u2010specific risk factors and radiological assessment"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8558-6674","authenticated-orcid":false,"given":"Simone Buchardt","family":"Brandt","sequence":"first","affiliation":[{"name":"Department of Urology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte","family":"Ibsen","sequence":"additional","affiliation":[{"name":"Department of Radiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitte Wrist","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Urology Herlev and Gentofte University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"B\u00f8ttcher","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Cardiology Regional Hospital G\u00f8dstrup  Herning Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernille Skjold","family":"Kingo","sequence":"additional","affiliation":[{"name":"Department of Urology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen Bjerggaard","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Urology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"WitjesJA BruinsHM Carri\u00f3nA CathomasR Comp\u00e9ratEM EfstathiouJA et al.European Association of Urology guidelines: muscle\u2010invasive and metastatic bladder cancer.https:\/\/uroweb.org\/guidelines\/muscle-invasive-and-metastatic-bladder-cancer.2023. 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