{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:00:33Z","timestamp":1767135633106,"version":"build-2238731810"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:00:00Z","timestamp":1726358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objectives of this study are as follows: to assess the uropathogen antibiogram at two tertiary hospitals in Victoria to look at the difference in susceptibility patterns, to assess whether national guideline recommendations were applicable and to assess the feasibility of local antibiogram analysis to guide development of hospital\u2010specific guidelines for empirical treatment of urosepsis and for pre\u2010operative prophylaxis for urological procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>All positive urine cultures analysed at Barwon Health and Monash Health, two tertiary hospitals in regional and metropolitan Victoria, Australia, respectively, between January 2019 and December 2020 were retrospectively identified. Data obtained included the organism cultured and their susceptibility profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Three thousand seven hundred and seventy\u2010seven positive urine cultures from Barwon Health and 6821 from Monash Health were identified. The most common uropathogen was\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Escherichia coli<\/jats:italic>\n                      <\/jats:styled-content>\n                      , which was cultured in 53.4% and 59.1% of urine cultures at Barwon Health and Monash Health, respectively. The main differences observed were in\n                      <jats:italic>Enterococcus<\/jats:italic>\n                      spp., which were cultured in 8.8% and 4.9% of cultures at Barwon Health and Monash Health, respectively, and\n                      <jats:italic>Candida<\/jats:italic>\n                      spp. in 4.2% and 1.5% of cultures at Barwon Health and Monash Health, respectively. The largest differences were found in fluoroquinolone resistance with 12.1% of organisms resistant to ciprofloxacin at Barwon Health compared to 6.4% at Monash Health and 7.1% of organisms resistant to vancomycin compared to 20.1% at Barwon Health and Monash Health, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that there is considerable variability in the uropathogens and their antimicrobial susceptibility profile in two large health services in the same state. We recommend that each centre performs regular analysis of their uropathogen antibiogram to develop local guidelines for treatment and pre\u2010operative prophylaxis for uropathogens.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.429","type":"journal-article","created":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T22:39:57Z","timestamp":1726439997000},"page":"1125-1130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Uropathogen antibiogram regional variations\u2014Are Australian antimicrobial guidelines appropriate?"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5168-6346","authenticated-orcid":false,"given":"Gavin","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Urology Monash Health  Melbourne Victoria Australia"},{"name":"Department of Surgery, School of Clinical Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0289-539X","authenticated-orcid":false,"given":"James Antony Sidney","family":"Sewell","sequence":"additional","affiliation":[{"name":"Department of Urology Monash Health  Melbourne Victoria Australia"},{"name":"Department of Urological Surgery, Barwon Health University Hospital Geelong  Geelong Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Bartolo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Barwon Health University Hospital Geelong  Geelong Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelia","family":"Pearce","sequence":"additional","affiliation":[{"name":"Department of Urological Surgery, Barwon Health University Hospital Geelong  Geelong Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Owen","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Geelong Laboratory Australian Clinical Laboratories  Geelong Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Grills","sequence":"additional","affiliation":[{"name":"Department of Urological Surgery, Barwon Health University Hospital Geelong  Geelong Victoria Australia"},{"name":"Department of Surgery, School of Medicine Deakin University  Geelong Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-019-03071-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-13"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.5455\/jrmds.2016436"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.24875\/CIRU.18000494"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3240268"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100960050440"},{"key":"e_1_2_7_8_1","unstructured":"Principles of surgical antibiotic prophylaxis. Therapeutic guidelines 2024 August 2022 [cited]. Available from:https:\/\/www.tg.org.au"},{"key":"e_1_2_7_9_1","volume-title":"European Association of Urology Guidelines 2021 Edition, Vol. presented at the EAU Annual Congress Milan 2021","author":"Bonkat G","year":"2021"},{"key":"e_1_2_7_10_1","unstructured":"Sepsis and septic shock from a urinary tract source in adults. Therapeutic guidelines 2021 March 2021 [cited]. Available from:https:\/\/www.tg.org.au"},{"key":"e_1_2_7_11_1","unstructured":"Surgical prophylaxis for urological surgery. Therapeutic guidelines 2021 March 2021 [cited]. Available from:https:\/\/www.tg.org.au"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000509"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.2382"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlab127"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164306"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00003-20"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c2096"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/664768"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-021-00939-2"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-90949-2"}],"updated-by":[{"DOI":"10.1002\/bco2.482","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000}}],"container-title":["BJUI Compass"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bco2.429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T20:51:38Z","timestamp":1759956698000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1002\/bco2.429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,15]]},"references-count":19,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/bco2.429"],"URL":"https:\/\/doi.org\/10.1002\/bco2.429","archive":["Portico"],"relation":{},"ISSN":["2688-4526","2688-4526"],"issn-type":[{"value":"2688-4526","type":"print"},{"value":"2688-4526","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,15]]},"assertion":[{"value":"2023-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}