{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T14:35:57Z","timestamp":1780756557632,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to assess the precision and safety of targeted microwave ablation (TMA) using organ\u2010based tracking (OBT) fusion, in patients with intermediate risk prostate cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and method<\/jats:title><jats:p>We conducted a prospective, multicentric trial. Eligible patients had a prostate\u2010specific antigen (PSA)\u2009&lt;\u200920\u2009ng\/mL, a magnetic resonance imaging (MRI)\u2010visible index tumour of Gleason score 3\u2009+\u20094, with largest axis \u226415\u2009mm and distant of at least 5\u2009mm from the rectum and apex. TMA was performed with microwave needle applicator using OBT fusion, with a transperineal or a transrectal approach. In this interim analysis, we evaluated precision, safety, urinary and sexual outcomes, and PSA density kinetics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At this point, 37 patients were treated in five centres. Median (interquartile range) age is 68 (63\u201372)\u00a0years. Baseline median prostate volume and PSA are of 45 (34\u201357)\u00a0mL and 8 (6.2\u201310.8)\u00a0ng\/mL, respectively. Median largest tumour axis on T2W MRI is of 11\u2009mm (10\u201313). Patients were treated under general anaesthesia or conscious IV sedation in an outpatient setting. Anaesthesia had a median duration of 78 (66\u201390)\u00a0min. A median number of 3 (2\u20134) 12\u2010W ablations of 2 to 5\u2009min were performed per patient. After a median follow\u2010up of 6 (2.4\u201310)\u00a0months, we observed 58 adverse events (AE) in 22 patients. These were of Common Terminology Criteria for Adverse Events (CTCAE) grade 1, 2 and 3 in 43 (74%), 13 (22%) and 2 (4%) cases. Six (15%) patients had an acute urinary retention, five of which considered as severe AE because of rehospitalisation. We did not observe any significant difference in International Prostate Symptom Score (IPSS), Male Sexual Health Questionnaire\u2010ejaculatory dysfunction (MSHQ\u2010EjD) and International Index of Erectile Function (IIEF5) from baseline to last follow\u2010up. Median PSA density evolved from 0.2 (0.1\u20130.3) at baseline to 0.1 (0.07\u20130.16) at 12\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These preliminary results suggest that TMA using OBT fusion is precise and safe in patients with intermediate risk localised prostate cancer. Further inclusions and follow\u2010up are needed to assess oncological outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bco2.444","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T02:40:37Z","timestamp":1730342437000},"page":"1307-1313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Targeted microwave ablation of localised prostate cancer: Initial results of VIOLETTE trial"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5827-9567","authenticated-orcid":false,"given":"Nicolas Barry","family":"Delongchamps","sequence":"first","affiliation":[{"name":"Department of Urology, Cochin Hospital, Assistance Publique \u2013 H\u00f4pitaux de Paris Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Peltier","sequence":"additional","affiliation":[{"name":"Department of 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