{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:35:12Z","timestamp":1784651712491,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T00:00:00Z","timestamp":1732406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the health utility values (HUVs) of overactive bladder (OAB), defined as urinary urgency, usually accompanied by urinary daytime or nocturnal frequency, with or without urinary incontinence, among adults aged \u226565\u2009years and to assess the HUV decrements (disutilities) of OAB according to its severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional Internet\u2010based study was conducted between 2 and 9 November 2023, with quota sampling with equal probability for each sex and age group (age 65\u201374\u2009years and \u226575\u2009years). OAB was defined as an urgency score of \u22652 points and a total score of \u22653 points based on the Overactive Bladder Symptom Score. OAB severity was categorized as mild (total score, \u22645 points) or moderate\u2010to\u2010severe (total score, 6\u201315 points). HUVs were measured using the EuroQol five\u2010dimension five\u2010level value set for the Japanese population. Multivariable linear regression models were fitted to estimate the covariate\u2010adjusted disutilities of OAB. We selected eight covariates (age, sex, body mass index, education, income, smoking, alcohol use, and comorbidities) as potential confounders based on previous studies. The sample size was determined based on previous studies without statistical power calculations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 998 participants (51.9% male; mean age, 73.2\u00a0years), 158 (15.9%) had OAB, of whom 87 (8.8%) had moderate\u2010to\u2010severe OAB. The mean HUVs for participants with mild and moderate\u2010to\u2010severe OAB were 0.874 and 0.840, respectively, which were lower compared with the HUV for those without OAB (0.913). After adjusting for relevant covariates, disutilities (95% confidence intervals [CIs] and\n                      <jats:italic>p<\/jats:italic>\n                      values) for mild and moderate\u2010to\u2010severe OAB were \u22120.0334 (\u22120.0602 to \u22120.0066,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014) and \u22120.0591 (\u22120.0844 to \u22120.0339,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Consistent with previous HUV studies on OAB, our results demonstrated that the prevalence of OAB was associated with substantially lower HUV. The results demonstrate that increased OAB severity is associated with greater disutility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.471","type":"journal-article","created":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T21:40:33Z","timestamp":1732484433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Health utility value of overactive bladder in Japanese older adults"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7709-8278","authenticated-orcid":false,"given":"Takashi","family":"Yoshioka","sequence":"first","affiliation":[{"name":"Health Technology Assessment Unit, Department of Preventive Medicine and Public Health Keio University School of Medicine  Tokyo Japan"},{"name":"Institute of Clinical Epidemiology Showa University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0109-7425","authenticated-orcid":false,"given":"Kenji","family":"Omae","sequence":"additional","affiliation":[{"name":"Department of Innovative Research and Education for Clinicians and Trainees (DiRECT) Fukushima Medical University Hospital  Fukushima Japan"},{"name":"Department of Health Promotion and Human Behavior, Graduate School of Medicine\/School of Public Health Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Funada","sequence":"additional","affiliation":[{"name":"Health Technology Assessment Unit, Department of Preventive Medicine and Public Health Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Minami","sequence":"additional","affiliation":[{"name":"Division of Quality Assurance Programs Institute for Cancer Control, National Cancer Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rei","family":"Goto","sequence":"additional","affiliation":[{"name":"Graduate School of Health Management Keio University  Kanagawa Japan"},{"name":"Graduate School of Business Administration Keio University  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.08.031"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.02.038"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2010.08.039"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-023-03530-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000001344"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23513"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2024.1345866"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2019.11.024"},{"key":"e_1_2_9_10_1","unstructured":"Project information|Vibegron for treating symptoms of overactive bladder ID6300|Guidance|NICE. 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