{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:48:34Z","timestamp":1788364114500,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess long\u2010term outcomes (up to 10\u00a0cycles) of repeated intradetrusor botulinum toxin (BoNT) utilisation in multiple sclerosis (MS) and idiopathic overactive bladder (OAB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This is a retrospective, international, multi\u2010centre, observational cohort study of patients diagnosed with MS and neurogenic OAB and treated with intradetrusor BoNT between January 2005 and January 2020 (just prior to COVID\u201019 interruption). Dose, efficacy, duration of effect, International Consultation on Incontinence Questionnaire Overactive Bladder (ICIQ\u2010OAB) and International Consultation on Incontinence Questionnaire Urinary Incontinence (ICIQ\u2010UI) measures and complication rates were recorded. Comparisons were made to those with idiopathic OAB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven hundred and ninety\u2010two patients received intradetrusor BoNT treatment (104 had MS with neurogenic OAB and 688 had idiopathic OAB). Patients with MS were more likely to receive higher doses of BoNT in all cycles. Self\u2010reported efficacy ranged from 85.7 to 100% (MS) and 87.2 to 100% (idiopathic) with MS patients reporting increased efficacy in cycles 1\u20133 comparatively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Duration of effect ranged from 4.5 to 9\u00a0months with a reduction in the MS cohort between cycles 1 and 10 (median 8\u00a0months vs. 5\u00a0months, <jats:italic>p<\/jats:italic>\u2009=\u20090.0156).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with MS and neurogenic OAB have a good therapeutic effect from intradetrusor BoNT that is sustained over at least 10\u00a0cycles with significant reduction in the duration of action with subsequent cycles.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bco2.479","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T05:57:24Z","timestamp":1734587844000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long\u2010term follow\u2010up of intradetrusor botulinum toxin utilisation: A comparison of patients with multiple sclerosis and idiopathic overactive bladder"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2471-4126","authenticated-orcid":false,"given":"William","family":"Chui","sequence":"first","affiliation":[{"name":"Department of Urology, Western Health University of Melbourne  Melbourne Australia"},{"name":"Department of Urology, Eastern Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7387-5084","authenticated-orcid":false,"given":"Joshua","family":"Kealey","sequence":"additional","affiliation":[{"name":"Department of Urology, Eastern Health  Melbourne Australia"},{"name":"Eastern Health Clinical School Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry H.","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Urology, Western Health University of Melbourne  Melbourne Australia"},{"name":"Department of Urology, Eastern Health  Melbourne Australia"},{"name":"Eastern Health Clinical School Monash University  Melbourne Australia"},{"name":"Department of Urology Nottingham University Hospitals NHS Trust  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garson","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Urology, Western Health University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Bazo","sequence":"additional","affiliation":[{"name":"Department of Urology Nottingham University Hospitals NHS Trust  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Parkinson","sequence":"additional","affiliation":[{"name":"Department of Urology Nottingham University Hospitals NHS Trust  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8565-1301","authenticated-orcid":false,"given":"Helen E.","family":"O'Connell","sequence":"additional","affiliation":[{"name":"Department of Urology, Western Health University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Gani","sequence":"additional","affiliation":[{"name":"Department of Urology, Western Health University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007035"},{"key":"e_1_2_9_3_1","unstructured":"CandaMS.Prevalence and incidence of MS in Canada and around the world 2020. 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