{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:56:44Z","timestamp":1787162204047,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2025,2]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To investigate the feasibility, oncological efficacy and safety of robotic segmental ureterectomy (SU) for treating patients with localised upper tract urothelial carcinoma (UTUC). A key aspect of this research involves utilising Black Eye\u2122 Endoscopic Marker Ink to delineate the boundary of the tumour in the ureter, helping to ensure precise surgical intervention and reducing the risk of positive surgical margin.<\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n In a prospective non\u2010randomised trial from January 2018 to December 2022, patients with localised UTUC confirmed by CT\u2010urography were enrolled. A Multidisciplinary Team assessed patients for suitability for kidney\u2010sparing surgery (KSS) with SU, marked by endoscopic Black Eye\u2122 Endoscopic Marker Ink. Black Eye Endoscopic Marker Ink marking aimed to enhance surgical precision by delineating clear resection margins. The primary endpoints were the feasibility of the technique, local and bladder recurrence rates and surgical outcomes. Propensity score matching was used for a balanced comparison to the standard treatment Radical Nephroureterectomy (RNU).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Thirty patients underwent SU, in the period of study with only one local recurrence reported with a median follow\u2010up time of 35\u2009months. SU was associated with a significantly shorter operative time (41\u2009minutes less on average,\n p<\/jats:italic>\n \u00a0<\u20090.001) than RNU. Tumour size was significantly larger in the RNU group (median size 42.5\u2009mm, IQR: 30\u201360.5) compared to the SU group (median size 30\u2009mm, IQR: 20\u201335) (\n p<\/jats:italic>\n \u00a0=\u20090.007), potentially indicating selection bias towards RNU for more advanced cases. No significant difference between the groups was found in the post\u2010operative Clavien\u2010Dindo complication score nor in oncological outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n SU with Black Eye\u2122 Endoscopic Marker Ink marking is a viable KSS technique that offers a safe and effective alternative to RNU for patients with a single tumour, no longer than 30\u2009mm and of low grade. This novel approach is promising in lowering the risk of positive margins, ensuring cancer control and preserving renal function.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/bco2.502","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T07:40:32Z","timestamp":1739950832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Precision in kidney\u2010sparing surgery: Robot\u2010assisted ureterectomy with novel Black Eye\u2122 Ink"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2170-3771","authenticated-orcid":false,"given":"Hayder","family":"Alhusseinawi","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Urology G\u00f8dstrup Hospital G\u00f8dstrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1416-2153","authenticated-orcid":false,"given":"Naomi","family":"Nadler","sequence":"additional","affiliation":[{"name":"Department of Urology Zealand University Hospital Roskilde Denmark"},{"name":"Institute for Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene Reif","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Urology Zealand University Hospital Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Luis","family":"V\u00e1squez","sequence":"additional","affiliation":[{"name":"Department of Urology Zealand University Hospital Roskilde Denmark"},{"name":"Institute for Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Norus","sequence":"additional","affiliation":[{"name":"Department of Urology Zealand University Hospital Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nessn","family":"Azawi","sequence":"additional","affiliation":[{"name":"Department of Urology Zealand University Hospital Roskilde Denmark"},{"name":"Institute for Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21654"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.05.079"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.11.094"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2022.03.027"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24135"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.07.014"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.12.018"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.10960.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2023.04.013"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-023-01265-y"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2021.05.010"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/08941939.2018.1457192"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.08.008"}],"container-title":["BJUI Compass"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bco2.502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T13:41:42Z","timestamp":1759930902000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1002\/bco2.502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/bco2.502"],"URL":"https:\/\/doi.org\/10.1002\/bco2.502","archive":["Portico"],"relation":{},"ISSN":["2688-4526","2688-4526"],"issn-type":[{"value":"2688-4526","type":"print"},{"value":"2688-4526","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2024-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e502"}}