{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:29Z","timestamp":1786977329922,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the relationship of preoperative prostate size, urinary retention, positive urine culture, and histopathological evidence of prostatitis or incidental prostate cancer on baseline and 3\u2010month nadir prostate\u2010specific antigen (PSA) value after Holmium laser enucleation of prostate (HoLEP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>Data from 90 patients who underwent a HoLEP by En\u2010bloc technique were analyzed. PSA values at baseline and at 3\u2010month follow\u2010up, preoperative urinary retention and urine culture status, weight of resected tissue, and histopathological evidence of prostatitis or prostate cancer were recorded. We performed univariable and multivariable gamma\u2010regression analyses to determine the impact of the aforementioned perioperative variables on preoperative PSA, 3\u2010month postoperative PSA, and change in PSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Serum PSA reduced significantly at 3\u00a0months from 6.3\u00a0\u00b1\u00a05.9\u00a0ng\/mL to 0.6\u00a0\u00b1\u00a00.6\u00a0ng\/mL. On both univariable and multivariable analysis, 3\u2010month nadir level was independent of all preoperative factors examined, except preoperative urinary retention status. Although patients with smaller prostate (resected tissue weight\u00a0&lt;40\u00a0g) had less percentile reduction in PSA when compared with those with larger prostate (resected tissue weight\u00a0&gt;80\u00a0g) (77.67% vs 89.06%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), patients from both these groups noted a similar PSA nadir level after 3\u00a0months (0.54 vs 0.56\u00a0ng\/dL). The drop in PSA level after HoLEP remained stable up to 1\u2010year follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PSA nadir 3\u00a0months after HoLEP remains relatively consistent across patients, regardless of preoperative prostate size, PSA value, urine culture status, and histopathological evidence of prostatitis or incidental prostate cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.68","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T02:32:13Z","timestamp":1609900333000},"page":"202-210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impact of perioperative factors on nadir serum prostate\u2010specific antigen levels after holmium laser enucleation of prostate"],"prefix":"10.1002","volume":"2","author":[{"given":"Mary","family":"Martos","sequence":"first","affiliation":[{"name":"Miller School of Medicine University of Miami Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8175-790X","authenticated-orcid":false,"given":"Jonathan E.","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Urology Miller School of Medicine University of Miami Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhumita","family":"Parmar","sequence":"additional","affiliation":[{"name":"Miller School of Medicine University of Miami Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Jain","sequence":"additional","affiliation":[{"name":"Miller School of Medicine University of Miami Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nachiketh","family":"Soodana\u2010Prakash","sequence":"additional","affiliation":[{"name":"Department of Urology Miller School of Medicine University of Miami Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanoj","family":"Punnen","sequence":"additional","affiliation":[{"name":"Department of Urology Sylvester Comprehensive Cancer Center Miller School of Medicine University of Miami Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L.","family":"Gonzalgo","sequence":"additional","affiliation":[{"name":"Department of Urology Sylvester Comprehensive Cancer Center Miller School of Medicine University of Miami Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Miao","sequence":"additional","affiliation":[{"name":"Division of Biostatistics Department of Public Health Sciences Sylvester Biostatistics and Bioinformatics Shared Resource Miller School of Medicine University of Miami Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isildinha M.","family":"Reis","sequence":"additional","affiliation":[{"name":"Division of Biostatistics Department of Public Health Sciences Sylvester Biostatistics and Bioinformatics Shared Resource Miller School of Medicine University of Miami Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Smith","sequence":"additional","affiliation":[{"name":"Miller School of Medicine University of Miami Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4273-5502","authenticated-orcid":false,"given":"Hemendra N.","family":"Shah","sequence":"additional","affiliation":[{"name":"Miller School of Medicine University of Miami Miami FL 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