{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:12:56Z","timestamp":1788358376927,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aim to compare salvage robotic radical prostatectomy (sRRP) for recurrent prostate cancer (PCa) after primary radiation (RT) versus focal therapy (FT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Patients who underwent sRRP following primary local therapy for PCa were identified. Perioperative findings and functional\/oncologic outcomes were compared in RT versus FT groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 112 patients were included, with 84 receiving RT and 28 FT as primary treatment. Median age and PSA were 68\u2009years and 5.4\u00a0ng\/mL, respectively. There was one rectal injury in the RT group. The overall 90\u2010day complications were significantly higher in RT group (33% vs. 11%, <jats:italic>p<\/jats:italic>\u2009=\u20090.03). On multivariable analysis, history of RT and prolonged operative time were associated with a higher rate of 90\u2010day complications. The 6\u2010 and 12\u2010month continence rates were higher in FT group (50% vs. 20%, <jats:italic>p<\/jats:italic>\u2009=\u20090.02 and 69% vs. 33%, <jats:italic>p<\/jats:italic>\u2009=\u20090.03). Potency at 12\u2009months was better preserved in FT group (46% vs. 12%, <jats:italic>p<\/jats:italic>\u2009=\u20090.01). On final sRRP pathology, the rates of grade group\u2009\u2265\u20094 (51% vs. 36%, <jats:italic>p<\/jats:italic>\u2009=\u20090.2), pT3 (69% vs. 75%, <jats:italic>p<\/jats:italic>\u2009=\u20090.6), positive nodes (30% vs. 18%, <jats:italic>p<\/jats:italic>\u2009=\u20090.2) and positive margins (33% vs. 39%, <jats:italic>p<\/jats:italic>\u2009=\u20090.5) were similar for RT versus FT, respectively. The 3\u2010year biochemical recurrence\u2010free survival was 86% for RT versus 94% for FT (<jats:italic>p<\/jats:italic>\u2009=\u20090.6).<\/jats:p><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>sRRP for recurrent PCa after FT is associated with lower complications and higher urinary continence and potency rates than patients who received primary RT.<\/jats:p><\/jats:sec><\/jats:sec>","DOI":"10.1002\/bco2.70019","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T08:35:04Z","timestamp":1746174904000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The outcomes of salvage robotic radical prostatectomy following radiation versus focal therapy: Does the primary treatment modality matter?"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7368-7240","authenticated-orcid":false,"given":"Alireza","family":"Ghoreifi","sequence":"first","affiliation":[{"name":"USC Institute of Urology, Catherine and Joseph Aresty Department of Urology, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo Storino","family":"Ramacciotti","sequence":"additional","affiliation":[{"name":"USC Institute of Urology, Catherine and Joseph Aresty Department of Urology, Keck School of Medicine University of Southern California  Los Angeles California USA"},{"name":"Center for Image\u2010Guided Surgery, Focal Therapy and Artificial Intelligence for Prostate Cancer, Keck School of Medicine University of Southern California  Los Angeles California 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Joseph Aresty Department of Urology, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiran","family":"Konganige","sequence":"additional","affiliation":[{"name":"USC Institute of Urology, Catherine and Joseph Aresty Department of Urology, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju","family":"Aron","sequence":"additional","affiliation":[{"name":"Department of Pathology Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarmad","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology University of Southern California Norris Comprehensive Cancer Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Jadvar","sequence":"additional","affiliation":[{"name":"Department of Radiology Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1984-3556","authenticated-orcid":false,"given":"Hooman","family":"Djaladat","sequence":"additional","affiliation":[{"name":"USC Institute of Urology, Catherine and Joseph Aresty Department of Urology, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Sotelo","sequence":"additional","affiliation":[{"name":"USC Institute of Urology, Catherine and Joseph Aresty Department of Urology, Keck School of Medicine University of Southern California  Los Angeles California 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