{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:18:22Z","timestamp":1767136702896,"version":"build-2238731810"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["CTRQQR\u20102021\\100004"],"award-info":[{"award-number":["CTRQQR\u20102021\\100004"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Standard of care (SOC) treatments for International Germ Cell Cancer Collaborative Group (IGCCCG) good prognosis stage II germ cell tumours (GCT) involve primary orchidectomy followed by combination chemotherapy for both seminoma and non\u2010seminomatous germ cell tumours (NSGCT). Alternatively, external beam radiotherapy may be used for seminoma and retroperitoneal lymph node dissection (RPLND) for NSGCT. While these treatments achieve high cure rates, they are associated with significant toxicities. De\u2010escalation strategies including three cycles of Carboplatin AUC10 or robotic RPLND with or without adjuvant chemotherapy have demonstrated potential to reduce treatment\u2010related toxicity in stage II seminoma while preserving oncological efficacy. However, these approaches are not widely adopted due to limited prospective comparative trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>The THERATEST trial is a prospective multicentre observational feasibility study evaluating participants receiving SOC treatments for good prognosis stage II seminoma and NSGCT or de\u2010escalated treatments for stage II seminoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Endpoints<\/jats:title>\n                    <jats:p>The primary endpoints are to assess feasibility of recruitment and retention. Secondary endpoints include assessing health\u2010related quality of life (HRQOL), sexual function and satisfaction, progression\u2010free survival (PFS), overall survival (OS) and safety and treatment\u2010related complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Thirty participants with good prognosis stage II seminoma or NSGCTs will be recruited over 18\u2009months into two cohorts: de\u2010escalation arm and SOC arm. The de\u2010escalation cohort will receive either Carboplatin AUC10 or robotic RPLND with or without adjuvant therapy depending on institutional SOC. Participants who decline or are ineligible for de\u2010escalation will receive SOC treatment: combination chemotherapy or radiotherapy for seminoma and combination chemotherapy for NSGCT. All participants will be followed for two years post\u2010treatment or until withdrawal. Data collection includes recruitment and retention rates, disease status, surgical outcomes, adverse events and patient\u2010reported outcomes using validated questionnaire: EORTC QLQ\u2010TC26, EORTC QLQ\u2010C30, Brief Male Sexual Function Inventory (BMSFI) and additional enquiries on anejaculation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Coordinating Centre<\/jats:title>\n                    <jats:p>\n                      THERATEST Trial Coordinator, Centre for Experimental Cancer Medicine, Barts Cancer Institute, Queen Mary University of London, Old Anatomy Building, Charterhouse Square, London, EC1M 6BQ|T: 0207882 8497|E:\n                      <jats:email>bci-theratest@qmul.ac.uk<\/jats:email>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>ISRCTN61007118.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.70057","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T04:59:16Z","timestamp":1753851556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapy de\u2010escalation for testicular cancer (THERATEST): A multi\u2010centre observational cohort feasibility study of de\u2010escalation therapies for good prognosis stage II germ cell tumours"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7578-5792","authenticated-orcid":false,"given":"Nasreen Abdul","family":"Aziz","sequence":"first","affiliation":[{"name":"Department of Medical Oncology St Bartholomew's Hospital, Barts Health NHS Trust  London UK"},{"name":"Centre for Experimental Cancer Medicine Barts Cancer Institute, Queen Mary University of London  London UK"},{"name":"School of Medicine School of Postgraduate Studies, Royal College of Surgeons in Ireland  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenrick","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology St Bartholomew's Hospital, Barts Health NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5876-6696","authenticated-orcid":false,"given":"Constantine","family":"Alifrangis","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology University College London Hospitals NHS Foundation Trust  London UK"},{"name":"National Institute for Health Research University College London Hospitals Biomedical Research Centre University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Peter MacCallum Cancer Centre  Melbourne 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