{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:40:07Z","timestamp":1792597207614,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the safety and efficacy of Holmium Laser Enucleation of the Prostate (HoLEP) in managing patients with a history of organ\u2010preserving treatments (OPT: Radiation Therapy \u2013 RT, High Intensity Focused Ultrasound \u2010 HIFU) for Organ\u2010Confined Prostate Cancer (OC\u2010PCa).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed men undergoing \u201cen\u2010bloc\u201d HoLEP between July 2017 and December 2023 from our institutional database to identify those with a history of OPT for OC\u2010PCa (study group). A 1:2 matched\u2010pair analysis was performed comparing these patients with a control group of men undergoing HoLEP for benign prostatic hyperplasia (BPH) without prior OPT. Demographic, perioperative and postoperative voiding parameters up to 1\u2009year, as well as complications, were compared between groups. Unpaired t\u2010tests were used for parametric variables and Wilcoxon Rank tests for non\u2010parametric variables. A p\u2010value&lt;0.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 660 patients, 15 had prior OPT before HoLEP. The time between OPT and HoLEP ranged from 3\u2010month to 12\u2010year. Associated urethral stricture and\/or extensive prostatic calcification were present in five patients. Demographic and preoperative parameters were similar between the groups. However, the study group patient had significantly less resected tissue and higher rate of urinary incontinence at 3\u2010month. Two patients (13.3%) continued to experience incontinence at 1\u2010year. There was no clinically significant difference in postoperative improvement in voiding parameters amongst both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HoLEP in patients with history of OPT for treatment of OC\u2010PCa is associated with a higher risk of transient urinary incontinence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bco2.70061","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T01:04:03Z","timestamp":1753146243000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A pilot study evaluating the safety and efficacy of En\u2010bloc holmium laser enucleation of the prostate in patients with a history of radiation therapy or high intensity focused ultrasound for management of organ confined prostate cancer with review of the literature"],"prefix":"10.1002","volume":"6","author":[{"given":"Renil S.","family":"Titus","sequence":"first","affiliation":[{"name":"Houston Methodist Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6131-4837","authenticated-orcid":false,"given":"Ansh","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6495-1054","authenticated-orcid":false,"given":"Joao G.","family":"Porto","sequence":"additional","affiliation":[{"name":"Desai Sethi Urology Institute University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6117-8086","authenticated-orcid":false,"given":"Jean C.","family":"Daher","sequence":"additional","affiliation":[{"name":"Desai Sethi Urology Institute University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele","family":"Raymo","sequence":"additional","affiliation":[{"name":"Desai Sethi Urology Institute University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maggie","family":"Meyreles","sequence":"additional","affiliation":[{"name":"Desai Sethi Urology Institute University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archan","family":"Khandekar","sequence":"additional","affiliation":[{"name":"Desai Sethi Urology Institute University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravindh","family":"Rathinam","sequence":"additional","affiliation":[{"name":"Desai Sethi Urology Institute University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Katz","sequence":"additional","affiliation":[{"name":"Desai Sethi Urology Institute University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Marcovich","sequence":"additional","affiliation":[{"name":"Desai Sethi Urology Institute University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4273-5502","authenticated-orcid":false,"given":"Hemendra N.","family":"Shah","sequence":"additional","affiliation":[{"name":"Desai Sethi Urology Institute University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Cancer Today. Accessed December 6 2024 https:\/\/gco.iarc.who.int\/today\/"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.08.005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.26491"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa074311"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000528559"},{"key":"e_1_2_9_7_1","unstructured":"Prostate Cancer \u2010 Uroweb. Accessed December 6 2024.https:\/\/uroweb.org\/guidelines\/prostate-cancer\/chapter\/treatment"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.11.006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.06.006"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000003698"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0360-3016(97)00928-0"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.05.010"},{"issue":"4","key":"e_1_2_9_13_1","first-page":"8903","article-title":"Preoperative symptoms predict continence after post\u2010radiation transurethral resection of prostate","volume":"24","author":"Polland A","year":"2017","journal-title":"Can J Urol"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2022.0571"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2013.0432"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-019-02913-2"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2024.04.022"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b13ca2"},{"key":"e_1_2_9_19_1","unstructured":"J Urol The frequency and morbidity of local tumor recurrence after definitive radiotherapy for stage C prostate cancer"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1096-9098(199702)64:2<127::aid-jso7>3.0.co;2-d"},{"issue":"2","key":"e_1_2_9_21_1","first-page":"560","article-title":"Post transurethral resection of prostate incontinence in previously radiated prostate cancer patients","volume":"5","author":"Hirshberg ED","year":"1998","journal-title":"Can J Urol"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00176-5"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000055773.91290.e8"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000132136.95221.63"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000152698.20487.0e"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.09.047"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22152"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)45519-4"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)38171-5"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2012.12.010"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(17)49985-x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.08.057"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000004088"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2019.11.014"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2024.4397"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2020.12.028"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cont.2025.101747"},{"key":"e_1_2_9_38_1","unstructured":"American Urological Association.Management of Outlet Obstruction Before and After Radiation Therapy for Prostate Cancer. Accessed April 22 2025.https:\/\/auanews.net\/issues\/articles\/2024\/march-2024\/management-of-outlet-obstruction-before-and-after-radiation-therapy-for-prostate-cancer"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-024-05424-0"}],"container-title":["BJUI Compass"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bco2.70061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:54:56Z","timestamp":1759946096000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1002\/bco2.70061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/bco2.70061"],"URL":"https:\/\/doi.org\/10.1002\/bco2.70061","archive":["Portico"],"relation":{},"ISSN":["2688-4526","2688-4526"],"issn-type":[{"value":"2688-4526","type":"print"},{"value":"2688-4526","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70061"}}