{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:19:28Z","timestamp":1773271168202,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2025,10]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To investigate whether storage or voiding symptoms respond more favourably to the use of Kranus Lutera, the first app\u2010based digital therapeutic for male lower urinary tract symptoms (LUTS), using detailed item\u2010level analysis of the IPSS questionnaire.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n The present data represent a post\u2010hoc analysis of the results of the BEST trial, a randomized controlled study evaluating the efficiency of the digital therapy Kranus Lutera. The study period lasted 12\u2009weeks, conducted between 04\/2023 and 11\/2023. We assessed the mean change from baseline to 12\u2009weeks for each of the seven IPSS items. Voiding symptoms (items 1, 3, 5 and 6) and storage symptoms (items 2, 4 and 7) were analysed separately.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Participants using the digital therapeutic demonstrated statistically significant improvements across all IPSS items. Compared to the control group, the intervention group showed a significant and clinically relevant improvement in the primary endpoint (IPSS), with an overall reduction of \u22127.0 points (95% CI: \u22128.1 to \u22125.9, p\u2009<\u20090.0001). Notably, improvements in storage symptoms were consistently larger than those in voiding symptoms. The analysis of individual IPSS questions showed the greatest changes in the overall cohort for questions 1, 2 and 7 (each p\u2009<\u20090.0001). Patients with the single diagnosis BPH (N40) showed the greatest score reduction in questions 2 and 5 (each p\u2009<\u20090.0001), patients with OAB (N32.8) in questions 2, 4 and 7 (each p\u2009<\u20090.0001) and patients with BPH and OAB (N40\u2009+\u2009N32.8) in questions 2, 3 and 7 (question 2 and 3 p\u2009<\u20090.0001, question 7 p\u2009=\u20090.0015). According to the analysis of individual IPSS questions, the greatest improvements were observed in frequency, nocturia and the feeling of incomplete bladder emptying.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n These findings suggest that a structured app\u2010based therapeutic may exert a stronger effect on storage symptoms than voiding symptoms in men with LUTS. This study confirms the value of the digital therapy as an integral part of the standard care for patients with male LUTS.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/bco2.70069","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T03:11:15Z","timestamp":1758856275000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Differential impact of digital therapy on storage and voiding LUTS: A post\u2010hoc IPSS analysis from the BEST randomized controlled trial"],"prefix":"10.1002","volume":"6","author":[{"given":"Sandra","family":"Sch\u00f6nburg","sequence":"first","affiliation":[{"name":"BG Klinikum Bergmannstrost Halle (Saale) Germany"},{"name":"Department of Urology and Kidney Transplantation Martin Luther University Halle (Saale) Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Gratzke","sequence":"additional","affiliation":[{"name":"Department of Urology University of Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Miller","sequence":"additional","affiliation":[{"name":"Charit\u00e9, Department of Urology University of Berlin Germany"},{"name":"Kranus Health GmbH Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Krieger","sequence":"additional","affiliation":[{"name":"Kranus Health GmbH Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Papp","sequence":"additional","affiliation":[{"name":"Kranus Health GmbH Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7071-8312","authenticated-orcid":false,"given":"Laura","family":"Wiemer","sequence":"additional","affiliation":[{"name":"Charit\u00e9, Department of Urology University of Berlin Germany"},{"name":"Kranus Health GmbH Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"issue":"6","key":"e_1_2_9_2_1","first-page":"957","article-title":"Empfehlungen des International Consensus Committees","volume":"1","author":"Cockett AT","year":"1991","journal-title":"Prog Urol"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00120-024-02398-0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2400290"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1016370925601"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.09.035"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24074"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00103-021-03407-9"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-020-00500-w"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13487"},{"key":"e_1_2_9_11_1","unstructured":"D'Agate S Development of a drug\u2010disease model describing individual IPSS trajectories in BPH patients: implication of disease progression and covariate factors on long term treatment response. 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