{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:48:28Z","timestamp":1788961708027,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Treatment with anticoagulants or antiplatelet drugs can provoke gross haematuria. In some cases, this may demask urologic malignancies. The goal of this study was to determine the influence of anticoagulants and antiplatelet drugs on the diagnosis and therapy of patients with gross haematuria who presented in the emergency department.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study analysed patients presenting with gross haematuria between January 1st, 2021 and December 31st, 2021 in a single centre university hospital. Information on pre\u2010existing conditions, anticoagulant and antiplatelet medication, and the further diagnostic and treatment course was gathered with a follow\u2010up time until December 31st, 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nearly half of the 541 patients (49.5%) presenting with gross haematuria were taking anticoagulant or antiplatelet medication. Patients receiving these medications were more likely to need bladder irrigation (p\u2009&lt;\u20090.001). They were also more likely to be hospitalized (p\u2009&lt;\u20090.001) and receive operative intervention (p\u2009=\u20090.011). The most common cause for haematuria was malignant tumours. A malignant urologic disease was diagnosed in 27% of the patients. Among those who were diagnosed with a malignant disease, the number of patients taking anticoagulant medication was higher (p\u2009=\u20090.005). In a follow\u2010up of 3\u00a0months, no thromboembolic events were observed after stopping or pausing anticoagulation or antiplatelet treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Clinically significant gross haematuria is often associated with the intake of anticoagulant or antiplatelet medication and can unmask underlying malignant diseases. The intake of anticoagulation or antiplatelet therapy should not be a reason to postpone diagnostic and therapeutic measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.70099","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T07:11:00Z","timestamp":1759907460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Gross haematuria in the era of anticoagulant therapy \u2013 Implications on treatment and diagnostic approaches in a large emergency department patient population"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9925-3100","authenticated-orcid":false,"given":"Yushan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Urology University of Regensburg, Caritas St. Josef Hospital  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Seidl","sequence":"additional","affiliation":[{"name":"Department of Urology University of Regensburg, Caritas St. Josef Hospital  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon Udo","family":"Engelmann","sequence":"additional","affiliation":[{"name":"Department of Urology University of Regensburg, Caritas St. Josef Hospital  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3132-0130","authenticated-orcid":false,"given":"Maximilian","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Urology University of Regensburg, Caritas St. Josef Hospital  Regensburg 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