{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:12:50Z","timestamp":1791310370227,"version":"4.3.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To develop a predictive model for symptomatic postoperative febrile urinary tract infections (UTIs) in children undergoing open reimplantation for vesicoureteral reflux (VUR) and evaluate the association with VUR recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>This multicentre retrospective study included children with unilateral VUR (grades III\u2013V) who underwent open Cohen or Lich\u2010Gregoir reimplantation (2010\u20132022), had recurrent febrile UTIs, and \u22651\u2009year follow\u2010up. Analyses used 10\u2010pooled multiple imputation, with complete case for sensitivity. Full and Least Absolute Shrinkage and Selection Operator (LASSO) Weibull regression models with centre clustering, bootstrapping, and 10\u2010fold cross\u2010validation identified predictors. Prediction used demographic, clinical, procedural and antibiotic factors. The non\u2010scaled LASSO model informed the nomogram, evaluated using C\u2010indices, calibration and decision curve analysis (DCA). UTI and VUR recurrence were analysed via cumulative incidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 404 children (median age 8 (6\u20139) years; follow\u2010up 2.3 (2.0\u20133.3) years, 233 complete\u2010case) were analysed. Median preoperative febrile UTIs were four, 74.5% had antibiotic resistance and median postoperative prophylaxis was two days. The 3\u2010year cumulative incidence of postoperative UTI was 27.2% (95% CI: 22.9\u201331.6). LASSO\u2010significant predictors included operative time (HR 1.10, 95% CI 1.03\u20131.16); in sensitivity analyses, prior injection (HR 2.08, 95% CI 1.88\u20132.30) and postoperative antibiotic duration (HR 0.81, 95% CI 0.69\u20130.97) were also significant. The nomogram included preoperative fever, antibiogram resistance, renal defect, VUR phase, prior injection, surgical indication, catheterization, hospitalization and stenting. The model performed well (C\u2010indices\u2009=\u00a00.743; calibration slope\u2009=\u00a01), with DCA supporting clinical utility for 10\u201340% predicted risk. Recurrent VUR grade \u2265II after 12\u2009months (3.3%\u201312.7% at 1\u20133\u00a0years, n\u2009=\u2009273) did not increase UTI risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children with unilateral dilating VUR remained at risk of postoperative febrile UTIs. The nomogram can assist in identifying high\u2010risk children for targeted interventions, but requires external validation and refinement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.70111","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T23:53:26Z","timestamp":1763423606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development of a prediction model for urinary tract infection risk after open reimplantation in children with primary unilateral vesicoureteral reflux: A multicentre study"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7102-098X","authenticated-orcid":false,"given":"Khadija","family":"Ismail","sequence":"first","affiliation":[{"name":"Lebanese University, Doctoral School of Sciences and Technology  Beirut Lebanon"},{"name":"Clinical and Epidemiological Research Laboratory, Faculty of Pharmacy Lebanese University  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8571-2768","authenticated-orcid":false,"given":"Mohamad","family":"Moussa","sequence":"additional","affiliation":[{"name":"Urology Department, Zahraa Hospital, University Medical Centre Lebanese University  Beirut Lebanon"},{"name":"Faculty of Medical Sciences, Urology Department Lebanese University  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Aoun","sequence":"additional","affiliation":[{"name":"Division of Paediatric Nephrology American University of Beirut\u2010Medical Centre  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4293-3314","authenticated-orcid":false,"given":"Mohamad","family":"Abou Chakra","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, Urology Department Lebanese University  Beirut 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