{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:39:40Z","timestamp":1792629580210,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011797","name":"Turun Yliopistollinen Keskussairaala","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011797","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to determine whether asymptomatic bacteriuria (ABU) increases the risk of infective complications requiring hospitalisation in patients undergoing Bacillus Calmette\u2010Gu\u00e9rin (BCG) instillations and consequently evaluate the need to screen asymptomatic patients for bacteriuria prior to BCG administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects\/patients and methods<\/jats:title>\n                    <jats:p>We analysed retrospectively all patients who received \u22651 BCG instillations as treatment of NMIBC in Helsinki University Hospital and Turku University Hospital during 2009\u20132018. Patients submitted urine specimens 1\u20137\u2009days prior to every BCG instillation. Urine culture results and possible antibiotic prophylaxis prior to BCG administration were recorded. ABU was classified as having a positive urine culture but no dysuria or fever. All hospital admissions because of urinary tract infections and other BCG\u2010related adverse effects within 2\u2009weeks of BCG administration were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We analysed 802 patients and 12\u2009968 BCG instillations. ABU was recorded prior to 2428 (19%) instillations among which antibiotics were used in 527 (22%). Hospital admission was recorded after 9 (0,3%) and 39 (0,4%) instillations in the ABU and in the sterile urine groups, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.9). Antibiotic prophylaxis did not affect the hospital admission rate (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.2).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BCG instillation with ABU is safe, and the results do not support routine screening of asymptomatic patients for bacteriuria prior to intravesical BCG immunotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.70117","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T14:05:51Z","timestamp":1765461951000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Time to abandon routine urine analysis prior to Bacillus Calmette\u2013Gu\u00e9rin administration in asymptomatic patients"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4461-3373","authenticated-orcid":false,"given":"Antti","family":"Nummi","sequence":"first","affiliation":[{"name":"Department of Urology Helsinki University and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9364-9754","authenticated-orcid":false,"given":"Pertti","family":"Nurminen","sequence":"additional","affiliation":[{"name":"Department of Urology Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli","family":"Kesti","sequence":"additional","affiliation":[{"name":"Department of Urology Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"H\u00f6german","sequence":"additional","affiliation":[{"name":"Department of Urology Turku University Hospital  Turku 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