{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:04:38Z","timestamp":1784181878415,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001779","name":"Monash University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aim to prospectively evaluate functional outcomes and toxicity following focal low\u2010dose\u2010rate (LDR) brachytherapy for low\u2013intermediate risk prostate cancer (PCa).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>LIBERATE is a clinical registry of men treated with focal LDR brachytherapy for low\u2013intermediate risk PCa since September 2019. Follow\u2010up occurred at 6\u2009weeks and every 3\u2009months thereafter. Outcomes were assessed using validated patient\u2010reported outcome measures (PROMs): IPSS, Expanded PCa Index Composite (EPIC) Bowel Assessment, and International Index of Erectile Function (IIEF\u20105). Adverse events (AEs) were clinically graded per Common Terminology Criteria for Adverse Events v5.0. Minimal important differences (MIDs) were defined as \u00b13.1 for IPSS, \u00b15 for EPIC bowel domain, and \u00b14 for IIEF\u20105.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 120 patients enrolled, 88\/120 (73.3%) had \u226512\u2009months follow\u2010up, and 79\/88 (89.7%) completed PROMs with a median (IQR) follow\u2010up of 33 (26\u201341) months. At 6\u00a0weeks, a transient, statistically and clinically significant increase in IPSS was observed, which returned to baseline by 12\u2009months (median IPSS: 6 at baseline, 12 at 6\u00a0weeks, 6 at 12\u2009months). EPIC bowel scores showed no significant changes, with 72 (91.1%) patients having rectal spacer. Among 66 sexually active men, 40 (60.6%) had no or mild erectile dysfunction (ED) at baseline, with a median IIEF\u20105 score of 22.5, decreasing to 22 at 6\u00a0weeks and plateauing at 21 at 6\u00a0months, none meeting MID criteria. For the 26 patients with mild to severe ED at baseline, the median IIEF\u20105 score declined from 10 at baseline to 5 at 6\u00a0months, with partial recovery followed by a drop to 5.5 at 2.5 and 3\u00a0years. Declines at 6\u00a0months and beyond 2\u00a0years were both statistically and clinically significant. No Grade \u22653 AEs were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Focal LDR brachytherapy is associated with favorable functional outcomes and minimal toxicity. Further studies are required to evaluate long\u2010term results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.70119","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T01:56:59Z","timestamp":1770861419000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional outcomes and toxicity following focal low\u2010dose\u2010rate brachytherapy for low\u2013intermediate risk prostate cancer"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8326-6175","authenticated-orcid":false,"given":"Mohammadmehdi","family":"Adhami","sequence":"first","affiliation":[{"name":"Department of Urology The Alfred Hospital  Melbourne Australia"},{"name":"School of Translational Medicine Monash University  Melbourne Australia"},{"name":"Icon Cancer Centre  Melbourne 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