{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:04:31Z","timestamp":1784181871222,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Accurate, reliable means to obtain fresh viable clinically localised prostate cancer tissue do not exist. We developed a method in which bespoke 3D\u2010printed moulds can be created for any prostate and allow for ex vivo sampling of magnetic resonance imaging (MRI)\u2010visible, biopsy\u2010proven cancer lesions. We sought to demonstrate the ability of our platform to obtain fresh viable prostate cancer tissue after robot\u2010assisted radical prostatectomy (RARP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Inclusion criteria were a patient that underwent MR\u2010fusion biopsy (UroNav, Philips) with a resulting biopsy proven Gleason Grade (GG)\u2009\u2265\u20092 target. STL files for prostate boundary and target regions of interest (ROI), created as part of fusion biopsy, were exported from the UroNav and imported into SolidWorks (Dassault), a solid modelling computer\u2010aided design and engineering application. A macro within SolidWorks was then applied to create a material\u2010optimised mould around the prostate with needle guides to allow for targeted sampling. The 3D mould was exported as an STL file and then 3D\u2010printed on a Stratasys Fortus 250 MC 3D Printer. During RARP, the specimen is extracted, the seminal vesicles detached and the prostate is placed in the mould for biopsy. The biopsy cores are sent to pathology for analysis and compared to specimens from the initial biopsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twelve patients with MRI\u2010visible lesions and biopsy proven GGG\u2009\u2265\u20092 cancer underwent RARP. In 12 out of 12 patients, ex vivo biopsies performed with the 3D\u2010printed mould yielded prostate tissue with cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our 3D\u2010printed mould platform allows for ex vivo sampling of MRI identified and previously biopsied prostate cancer at the time of RARP. The native, cancerous tissue may then be used to advance further research. The potential applications for a platform that can reliably sample living prostate cancer tissue are numerous, including the ability to advance future cancer research as well as other solid\u2010organ malignancies with targetable lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.70161","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:23:50Z","timestamp":1772958230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LUMBER: A feasible MRI\u2010based 3D printed mould platform for ex vivo sampling of prostate cancer"],"prefix":"10.1002","volume":"7","author":[{"given":"Chris","family":"Du","sequence":"first","affiliation":[{"name":"Department of Urology Loyola University Chicago  Maywood Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Rac","sequence":"additional","affiliation":[{"name":"Department of Urology Lexington Medical Center  West Columbia South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Lanzotti","sequence":"additional","affiliation":[{"name":"Department of Urology Loyola University Chicago  Maywood Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Urology VA Boston Healthcare System  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Loyola University Chicago  Maywood Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria M.","family":"Picken","sequence":"additional","affiliation":[{"name":"Department of Pathology Loyola University Chicago  Maywood Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guliz 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