{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:38:12Z","timestamp":1792460292750,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The purpose of this study is to investigate the impact of Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs) use on 90\u2010day postoperative outcomes and overall survival following partial nephrectomy (PN) for renal cell carcinoma (RCC), where type 2 diabetes mellitus (T2DM) is a common comorbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The TriNetX database was used to retrospectively identify T2DM patients who underwent PN. Patients prescribed GLP\u20101RAs were identified and matched in a 1:1 ratio with control patients who were not prescribed GLP\u20101RAs based on baseline characteristics, comorbidities, metformin and insulin prescription, and renal function laboratory values. For 90\u2010day postoperative adverse events, risk difference, risk ratio and odds ratio with 95% confidence intervals were calculated. Kaplan\u2013Meier analysis, log\u2010rank tests and multivariable Cox Proportional Hazards model were performed to measure the effect of GLP\u20101RAs use on overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Use of GLP\u20101RAs was associated with lower odds of acute kidney injury (odds ratio [OR]\u2009=\u20090.712), arrhythmia (OR\u2009=\u20090.725), readmission (OR\u2009=\u20090.8) and ileus (OR\u2009=\u20090.336) compared to the non\u2010GLP\u20101RAs group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 for each). Kaplan\u2013Meier analysis and log\u2010rank tests demonstrated improved 2\u2010year (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and 3\u2010year (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) overall survival among patients prescribed GLP\u20101RAs compared to those who were not.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Use of GLP\u20101RAs was associated with reduced incidence of 90\u2010day postoperative complications, such as acute kidney injury, arrhythmia, readmission and ileus, potentially contributing to improved overall survival. These results align with ongoing studies investigating the broader benefits of the use of GLP\u20101RAs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.70169","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T03:45:26Z","timestamp":1770090326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["GLP\u20101RA use improves outcomes post partial nephrectomy in T2DM patients with RCC: A TriNetX study"],"prefix":"10.1002","volume":"7","author":[{"given":"Sam","family":"Kwon","sequence":"first","affiliation":[{"name":"The George Washington University School of Medicine and Health Sciences  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Wardrop","sequence":"additional","affiliation":[{"name":"The George Washington University School of Medicine and Health Sciences  Washington District of Columbia 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