{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:07:29Z","timestamp":1787666849658,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objective of this study is to evaluate the safety and efficacy of Rez\u016bm water vapour energy therapy (WAVE) in Japanese patients with benign prostatic hyperplasia (BPH) continuing antithrombotic therapy and to validate the Okayama University Modified Clavien\u2010Dindo classification (OU\u2010mCD) for perioperative hematuria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We retrospectively analysed 80 consecutive patients who underwent WAVE from August 2023 to July 2024, including 37 (46.2%) continuing antithrombotic therapy perioperatively. Hematuria within 30\u2009days was graded using conventional Clavien\u2010Dindo classification and the OU\u2010mCD, a novel classification focusing on intervention necessity. We assessed clinically significant hematuria (Grade \u2265 Ib), catheter\u2010free rate, prostate volume reduction and haemoglobin change.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Clinically significant hematuria occurred in 21.6% (8\/37) of patients continuing antithrombotic therapy versus 4.7% (2\/43) without (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038). All 10 Grade \u2265 Ib cases occurred during hospitalization with the catheter in place and were managed conservatively with continuous bladder irrigation (median 1\u00a0day); none required transfusion or surgical reintervention. Only one patient required temporary drug discontinuation. Treatment efficacy did not differ by antithrombotic status: 86.2% achieved PVR\u2009&lt;\u200950\u2009ml with 44% mean prostate volume reduction. Multivariate analysis identified antithrombotic therapy as the sole independent risk factor for Grade \u2265 Ib hematuria (OR 5.46, 95% CI 1.06\u201328.16,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.042).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>WAVE can be safely performed with continued antithrombotic therapy. Whereas Grade \u2265Ib hematuria occurred in 25% of antiplatelet\/anticoagulant users (vs. 5% without), 75% had no significant bleeding, and all complications were managed conservatively without transfusion. The OU\u2010mCD provides precise complication stratification. These findings suggest outpatient procedures may be feasible with appropriate patient selection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.70170","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T04:15:56Z","timestamp":1770092156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Safety and efficacy of Rez\u016bm water vapour energy therapy in BPH patients receiving antithrombotic therapy: A Japanese single\u2010centre experience"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0163-1906","authenticated-orcid":false,"given":"Takatoshi","family":"Moriwake","sequence":"first","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"},{"name":"Department of Urology Okamura Isshindo Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Tominaga","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Kaku","sequence":"additional","affiliation":[{"name":"Department of Urology Okamura Isshindo Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Tsuboi","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasumi","family":"Yoshinaga","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Yamanoi","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsushi","family":"Kawada","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Sadahira","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0002-1592","authenticated-orcid":false,"given":"Kensuke","family":"Bekku","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Urology Okamura Isshindo Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoo","family":"Araki","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Clinical guideline for male lower urinary tract symptoms and benign prostatic hyperplasia","author":"Japan Urological Association","year":"2017"},{"key":"e_1_2_9_3_1","volume-title":"Labour and welfare. 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