{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:14:27Z","timestamp":1785428067491,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the treatment outcomes of 5\u2010aminolevulinic acid hydrochloride (5\u2010ALA) photodynamic diagnosis (PDD)\u2010assisted transurethral resection of bladder tumour (TURBT) (ALA PDD\u2010TURBT, hereinafter referred to as \u2018ALA\u2010PDD\u2019) exceeding 4\u2009h after ALA administration for non\u2013muscle\u2010invasive bladder cancer (NMIBC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>This retrospective single\u2010centre study included 386 patients who had undergone TURBT with or without 5\u2010ALA for NMIBC between January 2018 and December 2024. Patients who received 5\u2010ALA were divided into two groups based on 5\u2010ALA exposure times before TURBT: 2\u20134\u2009h and 4\u20138\u2009h groups. The diagnostic sensitivity and specificity of procedures performed after the two exposure times were calculated by comparing cystoscopy findings with pathological findings in the ALA\u2010PDD group. Recurrence\u2010free survival (RFS) and progression\u2010free survival (PFS) rates of NMIBC patients in the white\u2010light (WL) and ALA\u2010PDD groups were examined using Kaplan\u2013Meier curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      When the same lesion was evaluated using WL and fluorescent light (FL) modes, the sensitivity was 62.6% for the former and 93.2% for the latter. Furthermore, when the FL mode was divided into two ALA\u2010PDD groups, the sensitivity was 93.9% in the 2\u20134\u2009h group and 91.3% in the 4\u20138\u2009h group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.29). On the other hand, RFS was significantly longer in both the 2\u20134\u2009h and 4\u20138\u2009h ALA\u2010PDD groups than in the WL group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), with no significant difference in RFS between the 2\u20134\u2009h and 4\u20138\u2009h ALA\u2010PDD groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.105).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The clinical efficacy of ALA\u2010PDD, in terms of sensitivity and recurrence, was maintained even when the 5\u2010ALA administration time was extended from 2 to 4\u2009h to 2\u20138\u2009h prior to TURBT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.70173","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:47:07Z","timestamp":1770900427000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of extending the oral administration period of 5\u2010aminolevulinic acid on diagnostic accuracy and treatment outcomes for non\u2013muscle\u2010invasive bladder cancer"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9692-0239","authenticated-orcid":false,"given":"Hideo","family":"Fukuhara","sequence":"first","affiliation":[{"name":"Department of Urology and Center for Photodynamic Medicine Kochi Medical School  Nankoku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryu","family":"Shigehisa","sequence":"additional","affiliation":[{"name":"Department of Urology and Center for Photodynamic Medicine Kochi Medical School  Nankoku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinkuro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Urology and Center for Photodynamic Medicine Kochi Medical School  Nankoku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Fukata","sequence":"additional","affiliation":[{"name":"Department of Urology and Center for Photodynamic Medicine Kochi Medical School  Nankoku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Saito","sequence":"additional","affiliation":[{"name":"SBI Pharmaceuticals Co., Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Shibanaka","sequence":"additional","affiliation":[{"name":"SBI Pharmaceuticals Co., Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Urology and Center for Photodynamic Medicine Kochi Medical School  Nankoku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.03.059"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10374.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000060782.52358.04"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10090.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000100480.70769.0e"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.06.148"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.03.007"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2020.101999"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-024-02638-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2022.102757"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2023.103758"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nor086"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000195537"},{"key":"e_1_2_9_15_1","unstructured":"National Cancer Center Japan.Monitoring of cancer incidence in Japan\u2014survival 2012\u20132015. 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