{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:49:11Z","timestamp":1782103751965,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>Radical cystectomy (RC) is standard for muscle\u2010invasive disease (MIBC) and utilised frequently in high\u2010risk non\u2010muscle\u2010invasive bladder cancer (NMIBC). Pelvic lymph node dissection (PLND) is routinely performed during RC for MIBC, demonstrating a survival benefit. However, the oncologic value in NMIBC remains uncertain. As such, a systematic review was conducted to determine whether PLND confers an oncologic benefit in NMIBC patients undergoing RC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A systematic search of MEDLINE, Embase and PubMed (January 1989\u2013January 2025) was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta\u2010analyses guidelines (CRD42023443011). Eligible studies included NMIBC patients undergoing RC with or without PLND. Data extraction and quality assessment (ROBINS\u2010I, MINORS) were performed independently by two reviewers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010one retrospective studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200935\u2009793) met inclusion criteria. Lymph node positivity ranged from 0% to 13%. Comparative studies consistently demonstrated improved overall survival and cancer\u2010specific survival with PLND, particularly among pT1 subgroups (pooled 5\u2010year OS\u2009=\u200971.8%, 95% CI 59.3\u201384.3). Several studies demonstrated a dose\u2013response association between lymph node yield or dissection extent and improved outcomes. Benefits were inconsistent for Ta\/Tis disease. Pathological upstaging occurred in 16%\u201336% of clinically staged cohorts. However, study quality was moderate, with heterogeneity in PLND definitions, staging methods and adjuvant treatment use.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PLND appears to improve staging and survival in high\u2010risk NMIBC, especially pT1 disease. Routine PLND for low\u2010risk Ta\/Tis disease is unsupported. Standardised definitions of PLND extent and prospective evaluation are needed to confirm its therapeutic role.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.70201","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:50:02Z","timestamp":1777431002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lymph node dissection during cystectomy for non\u2010muscle\u2010invasive bladder cancer: A systematic review"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5921-9643","authenticated-orcid":false,"given":"Sean","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Urology Monash Health  Berwick Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucielle","family":"Standish","sequence":"additional","affiliation":[{"name":"Department of Urology Monash Health  Berwick 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