{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:33:29Z","timestamp":1787650409830,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate whether the preoperative FAN score\u2014composed of the fibrosis\u20104 (Fib\u20104) index, albumin\u2013bilirubin (ALBI) score and neutrophil\u2013lymphocyte ratio (NLR)\u2014predicts recurrence\u2010free, cancer\u2010specific and overall survival after radical cystectomy for bladder cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We retrospectively analysed 1121 patients who underwent radical cystectomy at 13 institutions between April 2010 and March 2024. Associations between the FAN score and recurrence\u2010free survival (RFS), cancer\u2010specific survival (CSS) and overall survival (OS) were evaluated. Prognostic performance was assessed in an independent cohort of 296 patients from three institutions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      FAN score distribution was 0 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009600, 53.5%), 1 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009409, 36.5%) and \u22652 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009112, 10.0%). Patients with a FAN score \u22652 had significantly worse RFS (median: not reached vs 12.3\u00a0months;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), CSS (not reached vs 22.8\u00a0months;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and OS (112.5 vs 16.1\u00a0months;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) than those with a FAN score \u22641. On multivariable analysis, a FAN score \u22652 was an independent predictor of poorer RFS (HR 2.12, 95% CI 1.55\u20132.91;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), CSS (HR 2.80, 95% CI 2.00\u20133.92;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and OS (HR 2.70, 95% CI 2.03\u20133.59;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). These associations were consistently observed in an independent cohort of 296 patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The FAN score is an independent prognostic marker of adverse outcomes after radical cystectomy for bladder cancer and may help stratify patients for perioperative management and follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.70221","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:05:56Z","timestamp":1777539956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Preoperative FAN score predicts survival outcomes after radical cystectomy for bladder cancer"],"prefix":"10.1002","volume":"7","author":[{"given":"Yu","family":"Ishizuya","sequence":"first","affiliation":[{"name":"Department of Urology The University of Osaka Graduate School of Medicine  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9369-4264","authenticated-orcid":false,"given":"Atsunari","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Department of Urology The University of Osaka Graduate School of Medicine  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7402-6164","authenticated-orcid":false,"given":"Shimpei","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Urology Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Ujike","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka Rosai Hospital  Sakai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Takao","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka General Medical Center  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Urology Toyonaka Municipal Hospital  Toyonaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Osaki","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka Keisatsu Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromu","family":"Horitani","sequence":"additional","affiliation":[{"name":"Department of Urology Higashiosaka City Medical Center  Higashiosaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshichika","family":"Iwanishi","sequence":"additional","affiliation":[{"name":"Department of Urology 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