{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T09:01:29Z","timestamp":1785315689658,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treatment of upper tract urothelial carcinoma (UTUC) depends on risk stratification and tumour characteristics. Kidney\u2010sparing surgery (KSS) is preferred for low\u2010risk disease, whereas radical nephroureterectomy (RNU) is the standard for high\u2010risk UTUC. Intravesical recurrences (IVR) are common after both treatment modalities, but their impact on survival remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the IVR rate and cumulative hazard following UTUC treatment and oncological outcomes based on the presence of IVR during follow\u2010up. Second, the relation between UTUC and IVR tumour grade in patients treated with endoscopic KSS (eKSS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single\u2010centre study, including non\u2010metastatic UTUC patients treated between 2010 and 2023. Analysis was performed in a cohort of patients without a history of bladder cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total 164 patients were selected; 85 treated with eKSS, 79 by RNU. Overall, 91 patients (55%) developed an IVR, 53 (62%) after eKSS and 38 (48%) after RNU, during a median follow\u2010up of 33\u2009months (IQR 11\u201372). eKSS\u2010treated patients showed a significantly higher cumulative hazard for IVR (HR 0.6, 95% CI 0.42\u20130.95,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). The CSS and MFS were comparable between patients with or without IVR during follow\u2010up. In patients treated by eKSS, we found IVR upgrading in 24% of patients treated with eKSS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients treated by eKSS showed a higher cumulative hazard of IVR, without an impact on oncological outcomes. These findings support the use of kidney\u2010sparing approaches in well\u2010selected cases and highlight the need for proper follow\u2010up including the bladder and evaluate IVR preventive measures as intravesical instillations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.70225","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T07:55:08Z","timestamp":1782719708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["When disease travels downstream: The effect of intravesical recurrences in patients treated for upper tract urothelial carcinoma"],"prefix":"10.1002","volume":"7","author":[{"given":"Orlane J. A.","family":"Figaroa","sequence":"first","affiliation":[{"name":"Department of Urology, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Medical Oncology, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8439-4571","authenticated-orcid":false,"given":"Sanne J.","family":"Jonker","sequence":"additional","affiliation":[{"name":"Department of Urology Amsterdam UMC, VU  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix J.","family":"Fris","sequence":"additional","affiliation":[{"name":"Faculty of medicine University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido M.","family":"Kamphuis","sequence":"additional","affiliation":[{"name":"Department of Urology, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriaan D.","family":"Bins","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Jeroen A.","family":"van Moorselaar","sequence":"additional","affiliation":[{"name":"Department of Urology Amsterdam UMC, VU  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5509-0213","authenticated-orcid":false,"given":"Joyce","family":"Baard","sequence":"additional","affiliation":[{"name":"Department of Urology, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2025.02.023"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euros.2022.04.007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2025.02.019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.07.027"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.04.052"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2015.24"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.11.035"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92066-3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10544"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.05.064"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.2128"},{"issue":"5","key":"e_1_2_9_13_1","article-title":"Single\u2010dose intravesical chemotherapy after nephroureterectomy for upper tract urothelial carcinoma","volume":"5","author":"Hwang EC","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350508"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euros.2023.01.004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2490-14-97"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2018.05.042"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.984014"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139976"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2021.0133"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2023.11.017"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11169.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01109-8"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.16902"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2020.0246"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau-23-112"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.12.006"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euros.2025.03.017"}],"container-title":["BJUI Compass"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bco2.70225","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bco2.70225","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bco2.70225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T08:28:53Z","timestamp":1785313733000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1002\/bco2.70225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/bco2.70225"],"URL":"https:\/\/doi.org\/10.1002\/bco2.70225","archive":["Portico"],"relation":{},"ISSN":["2688-4526","2688-4526"],"issn-type":[{"value":"2688-4526","type":"print"},{"value":"2688-4526","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]},"assertion":[{"value":"2026-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70225"}}