{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:47:00Z","timestamp":1782478020748,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the potential of the Haematuria Cancer Risk Score (HCRS) to improve the real\u2010world investigation pathway for suspected bladder cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Data were retrospectively analysed for all consecutive patients referred with suspected urinary tract cancer on a faster diagnostic pathway to five UK institutions between January and April 2025. The HCRS cut\u2010off score of \u226582 was used to define a \u2018HCRS high risk\u2019 population. The co\u2010primary outcomes were the ability to calculate HCRS in the referred population from the information provided by primary care and the cancer detection rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 1944 referrals were received, median age of 71\u2009years (IQR 61\u201378), 1186\/1944 (61%) were male, and 1586\/1944 (82%) had sufficient information to calculate the HCRS. Of the cohort with HCRS scores, overall 165\/1586 (10%) had bladder cancer. The HCRS was \u226582 in 176\/437 (40%) of those with non\u2010visible haematuria (NVH); in total, 6\/176 (3%) had bladder cancer; and using HCRS in the NVH group alone, no case of muscle\u2010invasive bladder cancer (MIBC) would have been missed. The HCRS was \u226582 in 1062\/1149 (92%) with visible haematuria (VH), of whom 150\/1062 (14%) had bladder cancer. Adopting a strategy of using HCRS and upper tract imaging in combination for the whole cohort would have resulted in two cases of NMIBC being missed for the NVH cohort and one case of NMIBC being missed for the VH cohort. No cases of MIBC or upper tract urothelial cancer would have been missed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HCRS is a simple innovation, which demonstrates clear potential when combined with upper tract imaging to improve current UK risk stratification to determine which patients referred with haematuria need flexible cystoscopy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.70233","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:31:07Z","timestamp":1780054267000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multicentre real\u2010world evaluation of the Haematuria Cancer Risk Score to risk\u2010stratify the detection of bladder cancer in patients referred from primary care"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6302-8209","authenticated-orcid":false,"given":"Tom","family":"Malik","sequence":"first","affiliation":[{"name":"Bristol Urological Institute, North Bristol NHS Trust  Bristol UK"},{"name":"Population Health Sciences, Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Denfhy","sequence":"additional","affiliation":[{"name":"Bristol Urological Institute, North Bristol NHS Trust  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hpone","family":"Theinkha Lin","sequence":"additional","affiliation":[{"name":"Bristol Urological Institute, North Bristol NHS Trust  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubna","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Bristol Urological Institute, North Bristol NHS Trust  Bristol 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