{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T09:01:30Z","timestamp":1785315690966,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2022\u201000544"],"award-info":[{"award-number":["2022\u201000544"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["22 2051"],"award-info":[{"award-number":["22 2051"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006636","name":"Forskningsr\u00e5det om H\u00e4lsa, Arbetsliv och V\u00e4lf\u00e4rd","doi-asserted-by":"publisher","award":["2024\u201001652"],"award-info":[{"award-number":["2024\u201001652"]}],"id":[{"id":"10.13039\/501100006636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005423","name":"Akademiska Sjukhuset","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005423","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009752","name":"Futurum - Akademin f\u00f6r H\u00e4lsa och V\u00e5rd, Region J\u00f6nk\u00f6pings l\u00e4ns","doi-asserted-by":"publisher","award":["996182"],"award-info":[{"award-number":["996182"]}],"id":[{"id":"10.13039\/501100009752","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009736","name":"Allm\u00e4nna Sjukhusets i Malm\u00f6 Stiftelse f\u00f6r Bek\u00e4mpande av Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009736","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to compare the effectiveness of software\u2010based fusion\u2010targeted biopsies (STBx) versus cognitive fusion\u2010targeted biopsies (CogTBx) in detecting prostate cancer (PCa) and clinically significant PCa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Men aged 30\u201385 were included in a target trial emulation if they had undergone a STBx or CogTBx of Prostate Imaging Reporting and Data System (PI\u2010RADS) 3\u20135 lesions in 2020\u20132024. Using log\u2010link binary regression models with inverse probability of treatment weighting to adjust for confounding, we estimated the associations between biopsy technique and detection of PCa and clinically significant PCa (Gleason \u22653\u2009+\u20094 and Gleason \u22654\u2009+\u20093) by use of adjusted relative risks (aRR) with 95% confidence intervals (CIs) obtained via bootstrapping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2092 men who underwent STBx and 7933 men who underwent CogTBx in 2020\u20132024 were identified in PCBase Xtend. The overall proportion diagnosed with PCa was 64%. STBx detected PCa with a slightly higher frequency (aRR, 1.05; 95% CI, 1.02\u20131.09), corresponding to an absolute increase of 3.3 percentage points (95% CI 1.2\u20135.3). The relative risk for detection of Gleason \u22654\u2009+\u20093 was somewhat larger (aRR, 1.13; 95% CI, 1.03\u20131.23). The largest relative difference for detection of PCa was observed in PI\u2010RADS 3 lesions (aRR, 1.12; 95% CI, 1.01\u20131.24), and this pattern became even more apparent when the outcome was restricted to clinically significant PCa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Software\u2010based fusion\u2010targeted biopsies detected slightly more PCa and clinically significant PCa compared to cognitive fusion\u2010targeted biopsies, particularly in men with PI\u2010RADS 3 lesions. Prioritizing PI\u2010RADS 3 lesions for software\u2010based targeted fusion biopsy could optimize diagnostic effectiveness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.70248","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T01:14:52Z","timestamp":1783905292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of software vs. cognitive\u2010based fusion\u2010targeted biopsies for prostate cancer diagnosis"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8906-6967","authenticated-orcid":false,"given":"Marcus","family":"Westerberg","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Gedeborg","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Garmo","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"J\u00e4derling","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery (MMK) Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Radiology Capio S:t G\u00f6rans Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4r","family":"Stattin","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3433-8873","authenticated-orcid":false,"given":"David","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of 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