{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T09:01:32Z","timestamp":1785315692850,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["971898"],"award-info":[{"award-number":["971898"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the synergistic effect and safety of sublingual isosorbide dinitrate (ISDN) to facilitate successful voiding trial after catheterization for acute urinary retention (AUR) secondary to benign prostatic hyperplasia (BPH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>\n                      In this randomized clinical trial, male patients aged \u2265\u200950\u2009years presenting with first\u2010episode AUR secondary to BPH at our urology emergency department were enrolled during 2019\u20132020. Participants were randomly assigned to receive either standard therapy (\u03b11\u2010blocker and 5\u03b1\u2010reductase inhibitor) alone (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940) or in combination with daily sublingual ISDN 10\u00a0mg for 21\u2009days (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940). Primary outcomes included successful voiding post\u2010catheter removal as trial without catheter (TWOC) and post\u2010void residual (PVR) volume. Secondary outcomes included post\u2010treatment prostate\u2010specific antigen (PSA) levels and adverse events. Data were analysed using independent\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests and chi\u2010square tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 80 men with similar baseline characteristics were enrolled (mean ages: 70.3\u2009\u00b1\u20097.97 in the ISDN group vs. 68.2\u2009\u00b1\u20098.73\u2009years in the controls). The rate of successful TWOC was significantly higher in the ISDN plus standard therapy group compared with standard therapy alone (50.0% vs. 22.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011). PVR volume decreased significantly after treatment in both groups (within\u2010group\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with a greater overall reduction observed in the ISDN group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). PSA levels remained stable, with no significant within\u2010 or between\u2010group differences. On multivariable logistic regression analysis, adjunctive ISDN therapy independently predicted successful TWOC (adjusted OR 3.27, 95% CI 1.23\u20138.70;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017). No serious adverse events were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adjunctive sublingual ISDN significantly improves urinary outcomes following AUR and reduces residual urine volume without increasing adverse events. This combination therapy offers a safe and effective strategy to improve the success of TWOC in patients with BPH\u2010related AUR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.70252","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T02:32:43Z","timestamp":1785205963000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Isosorbide dinitrate as an effective adjunct therapy for acute urinary retention: A randomized controlled trial"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2135-6757","authenticated-orcid":false,"given":"Salman","family":"Soltani","sequence":"first","affiliation":[{"name":"Kidney Transplantation Complications Research Center Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Department of Urology Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid Reza","family":"Ghorbani","sequence":"additional","affiliation":[{"name":"Kidney Transplantation Complications Research Center Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Department of Urology Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Tavakkoli","sequence":"additional","affiliation":[{"name":"Kidney Transplantation Complications Research Center Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Department of Urology Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Sadabadi","sequence":"additional","affiliation":[{"name":"Kidney Transplantation Complications Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0857-9929","authenticated-orcid":false,"given":"Seyyed Parham","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"Kidney Transplantation Complications Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid","family":"Zeinali","sequence":"additional","affiliation":[{"name":"Kidney Transplantation Complications Research Center Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Department of Urology Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20798"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2015.06.025"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2021.0278"},{"key":"e_1_2_10_5_1","unstructured":"NgM LeslieSW BaradhiKM.Benign Prostatic Hyperplasia. 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