{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:20:05Z","timestamp":1787718005907,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJUI Compass"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterize postoperative prostate\u2010specific antigen (PSA) kinetics after holmium laser enucleation of the prostate (HoLEP) in men with low\u2010risk prostate cancer (PCa) managed with active surveillance and to compare these with men without PCa, establishing a benchmark for expected PSA behaviour after HoLEP in low\u2010risk disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed a prospectively maintained HoLEP database at a tertiary centre from 2017 to 2025. Patients were stratified into benign and low\u2010risk PCa cohorts, with low\u2010risk PCa defined as Grade Group 1 disease. Patients with clinically significant PCa were excluded. PSA values were assessed at standardized postoperative time points up to 5\u00a0years. PSA reduction, PSA velocity (PSAV), PSA doubling time and surveillance outcomes were compared between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 769 patients were included (692 benign, 77 low\u2010risk PCa). Baseline characteristics were broadly comparable. Both groups demonstrated marked and similar PSA reductions after HoLEP, with no significant difference in percent PSA decline from baseline (91.6% vs. 91.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.953) or 3\u2010month PSA (0.39 vs. 0.40\u2009ng\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.858). PSA remained low throughout follow\u2010up in both cohorts. PSAV was numerically higher in the low\u2010risk cohort but did not differ significantly (0.127 vs. 0.036\u2009ng\/mL\/year,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.259). PSA doubling time was shorter in the low\u2010risk cohort, though not significantly (1.74 vs. 2.40\u2009years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.297). A greater proportion of low\u2010risk patients had PSA exceeding 1.0\u00a0ng\/mL, though this was not significant (23.4% vs. 17.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.249).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HoLEP produces a substantial PSA \u2018reset\u2019 with sustained low postoperative PSA in both benign and low\u2010risk PCa patients. Although low\u2010risk patients showed numerically higher PSAV, shorter PSA doubling time and greater likelihood of PSA exceeding 1.0\u00a0ng\/mL, overall postoperative PSA trajectories were statistically comparable between groups. These findings provide a reference for expected PSA kinetics after HoLEP in men with low\u2010risk PCa undergoing active surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bco2.70255","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T02:53:29Z","timestamp":1786416809000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Postoperative prostate\u2010specific antigen kinetics after holmium laser enucleation of the prostate in men with low\u2010risk prostate cancer"],"prefix":"10.1002","volume":"7","author":[{"given":"Hasim","family":"Bakbak","sequence":"first","affiliation":[{"name":"Desai Sethi Urology Institute University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurpremjit","family":"Singh","sequence":"additional","affiliation":[{"name":"Desai Sethi Urology Institute University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Abdelaziz","sequence":"additional","affiliation":[{"name":"Desai Sethi Urology Institute University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanita","family":"Velasquez Ospina","sequence":"additional","affiliation":[{"name":"Desai Sethi Urology Institute University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8482-6755","authenticated-orcid":false,"given":"Shlomo","family":"Resnik","sequence":"additional","affiliation":[{"name":"Desai Sethi Urology Institute University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor Stephen","family":"Nee","sequence":"additional","affiliation":[{"name":"University 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Urology Institute University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L.","family":"Gonzalgo","sequence":"additional","affiliation":[{"name":"Desai Sethi Urology Institute University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipen J.","family":"Parekh","sequence":"additional","affiliation":[{"name":"Desai Sethi Urology Institute University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4273-5502","authenticated-orcid":false,"given":"Hemendra Navinchandra","family":"Shah","sequence":"additional","affiliation":[{"name":"Desai Sethi Urology Institute University of Miami Miller School of Medicine  Miami Florida 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